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Credit kamagra jelly for women buy kamagra oral jelly nz. IStock Share Fast Facts New @HopkinsMedicine study finds African-American women with common form of hair loss at increased risk of uterine fibroids - Click to Tweet New study in @JAMADerm shows most common form of alopecia (hair loss) in African-American women associated with higher risks of uterine fibroids - Click to Tweet In a study of medical records gathered on hundreds of thousands of African-American women, Johns Hopkins researchers say they have evidence that women with a common form of hair loss have an increased chance of developing uterine leiomyomas, or fibroids.In a report on the research, published in the December 27 issue of JAMA Dermatology, the researchers call on physicians who treat women with central centrifugal cicatricial alopecia (CCCA) to make patients aware that they may be at increased risk for fibroids and should be screened for the condition, particularly if they have symptoms such as heavy bleeding and pain. CCCA predominantly affects black women and is buy kamagra oral jelly nz the most common form of permanent alopecia in this population. The excess scar tissue that forms as a result of this type of hair loss may also explain the higher risk for uterine fibroids, which are characterized by fibrous growths in the lining of the womb. Crystal Aguh, M.D., assistant professor of dermatology at the Johns buy kamagra oral jelly nz Hopkins University School of Medicine, says the scarring associated with CCCA is similar to the scarring associated with excess fibrous tissue elsewhere in the body, a situation that may explain why women with this type of hair loss are at a higher risk for fibroids.People of African descent, she notes, are more prone to develop other disorders of abnormal scarring, termed fibroproliferative disorders, such as keloids (a type of raised scar after trauma), scleroderma (an autoimmune disorder marked by thickening of the skin as well as internal organs), some types of lupus and clogged arteries.

During a four-year period from 2013-2017, the researchers analyzed patient data from the Johns Hopkins electronic medical record system (Epic) of 487,104 black women ages 18 and over. The prevalence of those with buy kamagra oral jelly nz fibroids was compared in patients with and without CCCA. Overall, the researchers found that 13.9 percent of women with CCCA also had a history of uterine fibroids compared to only 3.3 percent of black women without the condition. In absolute numbers, out of the 486,000 women who were reviewed, 16,212 had fibroids.Within that population, 447 had CCCA, of which 62 had fibroids. The findings translate to a fivefold increased risk of uterine fibroids in women with CCCA, compared buy kamagra oral jelly nz to age, sex and race matched controls.

Aguh cautions that their study does not suggest any cause and effect relationship, or prove a common cause for both conditions. €œThe cause of the link buy kamagra oral jelly nz between the two conditions remains unclear,” she says. However, the association was strong enough, she adds, to recommend that physicians and patients be made aware of it. Women with this type of scarring alopecia should be screened not only for fibroids, but also for other disorders associated with excess fibrous tissue, buy kamagra oral jelly nz Aguh says. An estimated 70 percent of white women and between 80 and 90 percent of African-American women will develop fibroids by age 50, according to the NIH, and while CCCA is likely underdiagnosed, some estimates report a prevalence of rates as high as 17 percent of black women having this condition.

The other authors on this buy kamagra oral jelly nz paper were Ginette A. Okoye, M.D. Of Johns Hopkins and Yemisi Dina of Meharry Medical College.Credit. The New England Journal of Medicine Share Fast Facts This study clears up how big an effect the buy kamagra oral jelly nz mutational burden has on outcomes to immune checkpoint inhibitors across many different cancer types. - Click to Tweet The number of mutations in a tumor’s DNA is a good predictor of whether it will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors.

- Click to Tweet The “mutational burden,” or the number of mutations present in a tumor’s DNA, is a good predictor of whether that cancer type will respond to a class of buy kamagra oral jelly nz cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows. The finding, published in the Dec. 21 New England Journal of Medicine, could be used to guide buy kamagra oral jelly nz future clinical trials for these drugs. Checkpoint inhibitors are a relatively new class of drug that helps the immune system recognize cancer by interfering with mechanisms cancer cells use to hide from immune cells. As a result, the drugs cause the immune system to fight cancer in the same way that it would fight an infection.

These medicines have had remarkable success in treating some types of cancers that historically have had poor prognoses, such as advanced melanoma buy kamagra oral jelly nz and lung cancer. However, these therapies have had little effect on other deadly cancer types, such as pancreatic cancer and glioblastoma. The mutational burden of certain tumor types has previously been proposed as an explanation for why certain cancers respond better than others to immune checkpoint inhibitors says study leader Mark buy kamagra oral jelly nz Yarchoan, M.D., chief medical oncology fellow. Work by Dung Le, M.D., associate professor of oncology, and other researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Cancer Institute for Cancer Immunotherapy showed that colon cancers that carry a high number of mutations are more likely to respond to checkpoint inhibitors than those that have fewer mutations. However, exactly how big an buy kamagra oral jelly nz effect the mutational burden has on outcomes to immune checkpoint inhibitors across many different cancer types was unclear.

To investigate this question, Yarchoan and colleagues Alexander Hopkins, Ph.D., research fellow, and Elizabeth Jaffee, M.D., co-director of the Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care and associate director of the Bloomberg~Kimmel Institute, combed the medical literature for the results of clinical trials using checkpoint inhibitors on various different types of cancer. They combined these findings with data buy kamagra oral jelly nz on the mutational burden of thousands of tumor samples from patients with different tumor types. Analyzing 27 different cancer types for which both pieces of information were available, the researchers found a strong correlation. The higher a cancer type’s mutational burden tends to be, the more likely it is to respond to checkpoint inhibitors. More than half of the differences in how well cancers responded to immune checkpoint inhibitors could be explained by the mutational burden buy kamagra oral jelly nz of that cancer.

€œThe idea that a tumor type with more mutations might be easier to treat than one with fewer sounds a little counterintuitive. It’s one of those things that doesn’t sound buy kamagra oral jelly nz right when you hear it,” says Hopkins. €œBut with immunotherapy, the more mutations you have, the more chances the immune system has to recognize the tumor.” Although this finding held true for the vast majority of cancer types they studied, there were some outliers in their analysis, says Yarchoan. For example, Merkel cell cancer, a rare and highly aggressive skin cancer, tends buy kamagra oral jelly nz to have a moderate number of mutations yet responds extremely well to checkpoint inhibitors. However, he explains, this cancer type is often caused by a virus, which seems to encourage a strong immune response despite the cancer’s lower mutational burden.

In contrast, the most common type of colorectal cancer has moderate mutational burden, yet responds poorly to checkpoint inhibitors for reasons that are still unclear. Yarchoan notes that buy kamagra oral jelly nz these findings could help guide clinical trials to test checkpoint inhibitors on cancer types for which these drugs haven’t yet been tried. Future studies might also focus on finding ways to prompt cancers with low mutational burdens to behave like those with higher mutational burdens so that they will respond better to these therapies. He and his colleagues plan to extend this line of research by investigating whether mutational burden might be a good predictor of whether cancers in individual patients might respond well to this class of immunotherapy drugs. €œThe end goal is precision medicine—moving beyond what’s true for big groups of patients to see whether we can use this information to help any given patient,” he says.

Yarchoan receives funding from the Norman &. Ruth Rales Foundation and the Conquer Cancer Foundation. Through a licensing agreement with Aduro Biotech, Jaffee has the potential to receive royalties in the future..

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The cards, he said, would be “actual discount cards for prescription drug copays.”advertisement Trump also bragged about a new regulation allowing states and pharmacies to import prescription drugs from Canada. While the administration did publish a Food and Drug Administration regulation on importation Thursday, states would still need to apply to participate and then would have to set up new programs to actually begin importing drugs.Health is kamagra legal secretary Alex Azar also sent a letter to congressional leadership formally “certifying” that importation can be done safely and that it would save the U.S. Money.

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The idea has is kamagra legal never been formally proposed or sketched out by health officials, though the New York Times reported this week that Trump officials had tried to convince the pharmaceutical industry to pay for similar cards worth $100. The drug industry refused.A spokesperson for PhRMA, the drug industry trade group, said that “one-time savings cards will neither provide lasting help, nor advance the fundamental reforms necessary to help seniors better afford their medicines.” Trump’s remarks followed a similarly puzzling press briefing orchestrated by two top administration health advisers. During a is kamagra legal Thursday afternoon call with reporters, the administration teased a “historic” health care plan likely to kickstart “the most consequential health care reform in American history.”The actual policies they announced, however, are simple, superficial, and non-binding executive orders.

Neither will improve the quality of Americans’ health care or lower its cost.The first, Azar said, is a declaration. €œIt is the policy of the United States that people who suffer from pre-existing is kamagra legal conditions will be protected” from discrimination by health insurers. He acknowledged the order was redundant.

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If Congress remains gridlocked on the issue then, he added, Trump would direct him to pursue other actions or regulations.“I don’t have details for you at this point on that,” he said.Throughout a 30-minute press call, Azar and Seema Verma, the administrator of the Centers for Medicare and Medicaid Services, struggled to provide any further detail. But they continually cast the actions as historic, the latest in a series of Trump administration attempts to play up health care actions in the final run-up to Election Day. On Sept.

13, Trump rolled out a series of actions on drug pricing that will be all but impossible to implement by Nov. 3, including a controversial plan to cap Medicare’s drug payment levels based on prices that pharmaceutical companies charge in other countries.The actions were widely viewed as motivated by election politics, not policy — Trump has sparred with drug manufacturers for years, but his administration has struggled to enact its own agenda on drug pricing thanks to a federal court setback, a series of internal conflicts, and steadfast industry opposition. Trump’s health care electioneering has even extended to his government’s widely criticized Covid-19 response.

Often, Trump’s misstatements have taken a markedly political tone and generated controversy regarding the role of high-ranking government scientists. In particular, Stephen Hahn, the commissioner of the Food and Drug Administration, was criticized in August for dramatically overstating the impact of blood plasma from recovered Covid-19 patients as a coronavirus treatment.The two executive actions fall dramatically short of the “full and complete” health care plan” Trump promised in July. During Thursday’s press call, both Azar and Verma officials struggled to provide detail or cast the actions as a comprehensive plan.

Azar was, at times, candid in acknowledging that the executive orders carried little force. The surprise billing order, he said, would require private-sector players like hospitals and insurance companies negotiate among themselves.“All the relevant players — hospitals, doctors, insurance companies — had better get their act together and get legislation passed through Congress that protects patients against surprise medical bills from anybody. Hospitals or doctors, doesn’t matter,” he said.

€œThose special interest groups need to sort it out and figure out how that would work.”The protections for patients with pre-existing conditions have been in force since 2014, and are among the most popular elements of the Affordable Care Act. The administration’s announcement on the stated protections is likely empty rhetoric. Many legal experts believe it is unlikely that the White House could enact similar protections without help from Congress.

The announcement comes in the face of intense criticism surrounding the Trump administration’s support for a lawsuit that would overturn the ACA in its entirety. The Supreme Court’s decision in the case this term could ultimately end the ACA’s expansion of state Medicaid programs, its protections for patients with pre-existing conditions, and, ironically, the very federal program that has allowed the Trump administration to attempt such drastic action to regulate lower drug prices.Azar and Verma also attempted to cast past health care actions, including a measure on hospital price transparency, as part of Trump’s new plan, perhaps in recognition of Trump’s precarious Election Day position on most health care issues.Trump trails his Democratic challenger, Joe Biden, on most health care issues, according to polls. Americans disapprove of the administration’s chaotic Covid-19 response by wide margins.

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WASHINGTON — President Trump on Thursday pledged to send $200 prescription drug coupons to 33 million Medicare beneficiaries “in the coming weeks,” a political ploy to curry favor with seniors who view drug prices as a priority.Trump’s promise comes less than six weeks before Election Day, and represents the latest step in his administration’s (and his campaign’s) efforts to amass health care talking points, even if buy kamagra oral jelly nz their actions do little to save Americans money.The administration is getting its authority to ship the coupons from a Medicare kamagra bestellen deutschland demonstration program, a White House spokesman told STAT in a statement. The nearly $7 billion required to send the coupons, he said, would come from savings from Trump’s “most favored nations” drug pricing proposal. That regulation has also not yet been implemented — meaning the Trump administration is effectively buy kamagra oral jelly nz pledging to spend $6.6 billion in savings that do not currently exist. The cards, he said, would be “actual discount cards for prescription drug copays.”advertisement Trump also bragged about a new regulation allowing states and pharmacies to import prescription drugs from Canada. While the administration did publish a Food and Drug Administration regulation on importation Thursday, states would still need to apply to participate and then would have to set buy kamagra oral jelly nz up new programs to actually begin importing drugs.Health secretary Alex Azar also sent a letter to congressional leadership formally “certifying” that importation can be done safely and that it would save the U.S.

Money. That’s a major buy kamagra oral jelly nz step in green-lighting widespread drug importation. Current law requires that importation can only happen if the secretary formally certifies it first. Azar is the first Department of Health and Human Services secretary in history to formally certify that importation is safe.advertisement Trump’s remarks came during a careening North Carolina speech address buy kamagra oral jelly nz on Trump’s “America First Health Care Plan,” which he had pledged to unveil for months.During the event, Trump attacked Democrats and his election opponent, Joe Biden, and insisted that he’d done more to reform U.S. Health care than any past administration.

(The health care law championed and signed by former president Barack Obama helped reduce the rate of Americans without insurance from 16% of the population in 2010 to 9% in 2016, and made other sweeping changes to the delivery of health care in buy kamagra oral jelly nz the U.S.)It is unclear whether Trump’s promises on $200 credits for prescription drug coupons will come to fruition. Under the Constitution, it is Congress, not the White House, that is empowered to spend taxpayer money, and it is unclear where the roughly $6.6 billion for the program would come from. The idea has never been formally proposed or sketched out by health officials, buy kamagra oral jelly nz though the New York Times reported this week that Trump officials had tried to convince the pharmaceutical industry to pay for similar cards worth $100. The drug industry refused.A spokesperson for PhRMA, the drug industry trade group, said that “one-time savings cards will neither provide lasting help, nor advance the fundamental reforms necessary to help seniors better afford their medicines.” Trump’s remarks followed a similarly puzzling press briefing orchestrated by two top administration health advisers. During a Thursday afternoon call with reporters, buy kamagra oral jelly nz the administration teased a “historic” health care plan likely to kickstart “the most consequential health care reform in American history.”The actual policies they announced, however, are simple, superficial, and non-binding executive orders.

Neither will improve the quality of Americans’ health care or lower its cost.The first, Azar said, is a declaration. €œIt is the policy of the United States that people who buy kamagra oral jelly nz suffer from pre-existing conditions will be protected” from discrimination by health insurers. He acknowledged the order was redundant. It mirrors protections enshrined buy kamagra oral jelly nz in the Affordable Care Act, the landmark health law that the Trump administration has asked a federal court to invalidate. The second order, Azar said, was a directive that he work with Congress to ban “surprise” out-of-network medical bills by Jan.

1 http://sw.keimfarben.de/generic-kamagra-online-for-sale/ buy kamagra oral jelly nz. If Congress remains gridlocked on the issue then, he added, Trump would direct him to pursue other actions or regulations.“I don’t have details for you at this point on that,” he said.Throughout a 30-minute press call, Azar and Seema Verma, the administrator of the Centers for Medicare and Medicaid Services, struggled to provide any further detail. But they continually cast the actions as historic, the latest in a buy kamagra oral jelly nz series of Trump administration attempts to play up health care actions in the final run-up to Election Day. On Sept. 13, Trump rolled buy kamagra oral jelly nz out a series of actions on drug pricing that will be all but impossible to implement by Nov.

3, including a controversial plan to cap Medicare’s drug payment levels based on prices that pharmaceutical companies charge in other countries.The actions were widely viewed as motivated by election politics, not policy — Trump has sparred with drug manufacturers for years, but his administration has struggled to enact its own agenda on drug pricing thanks to a federal court setback, a series of internal conflicts, and steadfast industry opposition. Trump’s health care electioneering has even extended to his buy kamagra oral jelly nz government’s widely criticized Covid-19 response. Often, Trump’s misstatements have taken a markedly political tone and generated controversy regarding the role of high-ranking government scientists. In particular, Stephen Hahn, the commissioner of the Food and Drug Administration, was criticized in August for dramatically overstating the impact of blood plasma from recovered Covid-19 patients buy kamagra oral jelly nz as a coronavirus treatment.The two executive actions fall dramatically short of the “full and complete” health care plan” Trump promised in July. During Thursday’s press call, both Azar and Verma officials struggled to provide detail or cast the actions as a comprehensive plan.

Azar was, at times, candid in acknowledging that buy kamagra oral jelly nz the executive orders carried little force. The surprise billing order, he said, would require private-sector players like hospitals and insurance companies negotiate among themselves.“All the relevant players — hospitals, doctors, insurance companies — had better get their act together and get legislation passed through Congress that protects patients against surprise medical bills from anybody. Hospitals or buy kamagra oral jelly nz doctors, doesn’t matter,” he said. €œThose special interest groups need to sort it out and figure out how that would work.”The protections for patients with pre-existing conditions have been in force since 2014, and are among the most popular elements of the Affordable Care Act. The administration’s announcement on the buy kamagra oral jelly nz stated protections is likely empty rhetoric.

Many legal experts believe it is unlikely that the White House could enact similar protections without help from Congress. The announcement comes in the face of intense criticism surrounding the Trump administration’s support for a lawsuit buy kamagra oral jelly nz that would overturn the ACA in its entirety. The Supreme Court’s decision in the case this term could ultimately end the ACA’s expansion of state Medicaid programs, its protections for patients with pre-existing conditions, and, ironically, the very federal program that has allowed the Trump administration to attempt such drastic action to regulate lower drug prices.Azar and Verma also attempted to cast past health care actions, including a measure on hospital price transparency, as part of Trump’s new plan, perhaps in recognition of Trump’s precarious Election Day position on most health care issues.Trump trails his Democratic challenger, Joe Biden, on most health care issues, according to polls. Americans disapprove of the administration’s chaotic Covid-19 response buy kamagra oral jelly nz by wide margins. And one recent Kaiser Family Foundation survey found a majority of voters trust Biden over Trump on protecting patients with pre-existing conditions, ensuring access to insurance, and protecting the Affordable Care Act, though Trump held a slight advantage on plans to tackle high drug prices..

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One is a re​turned traveller who is in hotel quarantine Ten are linked to a known case or cluster Three are locally acquired with their source still under investigation Eight of the new cases are linked to the Sydney CBD cluster, bringing the total number of cases in this cluster to 23. Of the new cases, two are household contacts of previously reported cases, three attended the City Tattersalls Club, and three were close contacts of people linked to this cluster. Further investigations have found one case reported yesterday is also linked kamagra australia to this cluster.

NSW Health is investigating whether the CBD cluster originated in the City Tattersalls Club and then spread to workplaces in the city and to households across Sydney and the Central Coast. To assist in identifying earlier and possible undiagnosed cases, NSW Health is asking anyone who attended the Club between 4 August 2020 – 18 August 2020 to get tested for COVID-19 and isolate until a negative test result is received. Genomic sequencing of the virus from cases in this cluster are related kamagra australia to other recent clusters in NSW.

This virus is genetically different to that of the Marriott Hotel security guard, who had a strain that had come from overseas. All identified close contacts of cases linked to this cluster are being contacted and told they must isolate for 14 days, get tested, kamagra australia get another test if any symptoms develop and stay isolated for the full 14 days, even if a negative test result is received within this period. Among the new cases today, two are household contacts of cases linked to Liverpool Hospital.

Prior to diagnosis many of the recently confirmed cases have attended a variety of locations and a full list of locations is available on the link below. New COVID-19 cases have visited the following locations in Mosman, St Ives and Rosebery and people attending at the same time must monitor for symptoms, get tested immediately if kamagra australia they develop and stay isolated until a negative test result is received. Archie Bear café, Mosman Rowers - 24 August 11am to 12 noon and Tuesday 25 August 9:00am to 9.30am Rosebery Post Shop, 371 Gardeners Rd, Rosebery - 26 August 1:30pm-1:40pm St Ives Shopping Centre, 166 Mona Vale Rd, St Ives - 24 August 2:30pm-3:30 pm NSW Health is treating 67 COVID-19 cases, including six in intensive care and four who are ventilated.

85 per cent of cases being treated by NSW Health are in non-acute, out-of-hospital care. Due to the widening spread of the CBD cluster across multiple locations in the Sydney and Central Coast, NSW Health is kamagra australia strongly advising people who live or work in these areas to not visit aged care facilities at this time. This is a precaution while the cluster is investigated, cases are identified and isolated and contact tracing is done.

NSW Health will continue to closely monitor the number and location of cases in Sydney and the Central Coast and will adjust the advice regarding visitor restrictions on aged care facilities according to the level of local risk. NSW Health kamagra australia will provide an update during the next week. COVID-19 continues to circulate in the community and we must all be vigilant.

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Confirmed cases to date Overseas2,067Interstate acquired89Locally acquired – contact of a confirmed case and/or in a known cluster1,296Locally acquired – contact not identified391Under investigation​1 Counts reported for a particular day may vary over time with ongoing enhanced surveillance activities. Returned travellers in hotel quarantine to date​​ Symptomatic travellers tested4,765Found positive122 As​ymptomatic travellers screened at a day 217,750Found positive88 Asymptomatic travellers screened at a day 1030,788​Found positive119​Video update​​NSW Health is investigating new cases of COVID-19 in relation to City Tattersalls Fitness Centre on Pitt Street.These cases attended the centre during the past few days, while unknowingly infectious and after being exposed to infections in the gym.Anyone who attended this venue on the following dates and times are considered to be close contacts and must immediately get tested for COVID-19, and self-isolate for 14 days since their last visit. Wednesday 19 August between 8am - 2pm Friday 21 August between 8am - kamagra australia 2pm, including.

Aqua Aerobics from 10am-10:45am Stretch Class from 11am – 11:50am Pump Class from 12:15pm - 1pm Sunday 23 August between 8am - 2pm Monday 24 August between 8am - 2pm Tuesday 25 August between 8am - 2pm Members who attended the gym on the above dates but outside those times should be on the alert for symptoms and get tested and self-isolate if symptoms do develop.A previously reported case attended one of the gaming areas of City Tattersalls on 24 August. Others who were in the gaming areas on this day must monitor for symptoms and get tested immediately if even the mildest symptoms develop. NSW Health is investigating whether the CBD cluster originated in the City Tattersalls Club and then spread to workplaces in the city and to households kamagra australia across Sydney and the Central Coast.

To assist in identifying undiagnosed earlier COVID cases, NSW Health is asking anyone who attended the Club between 4 August 2020 – 18 August 2020 to get tested for COVID-19 and isolate until a negative test result is received. A full list of COVID-19 testing clinics is available or people can visit their GP..

Fourteen new cases of COVID-19 were diagnosed in the 24 hours to http://sw.keimfarben.de/where-to-buy-generic-kamagra/ 8pm last night, bringing buy kamagra oral jelly nz the total number of cases in NSW to 3,844. Confirmed cases (including interstate residents in NSW health care facilities)3,844Deaths (in NSW from confirm​​ed cases)54Total tests carried out2,137,629 There were 24,632 tests reported in the 24-hour reporting period, compared with 30,282 in the previous 24 hours. Of the buy kamagra oral jelly nz fourteen new cases to 8pm last night. One is a re​turned traveller who is in hotel quarantine Ten are linked to a known case or cluster Three are locally acquired with their source still under investigation Eight of the new cases are linked to the Sydney CBD cluster, bringing the total number of cases in this cluster to 23. Of the new cases, two are household contacts of previously reported cases, three attended the City Tattersalls Club, and three were close contacts of people linked to this cluster.

Further investigations buy kamagra oral jelly nz have found one case reported yesterday is also linked to this cluster. NSW Health is investigating whether the CBD cluster originated in the City Tattersalls Club and then spread to workplaces in the city and to households across Sydney and the Central Coast. To assist in identifying earlier and possible undiagnosed cases, NSW Health is asking anyone who attended the Club between 4 August 2020 – 18 August 2020 to get tested for COVID-19 and isolate until a negative test result is received. Genomic sequencing of the virus from cases in this cluster are related to other recent buy kamagra oral jelly nz clusters in NSW. This virus is genetically different to that of the Marriott Hotel security guard, who had a strain that had come from overseas.

All identified close contacts of buy kamagra oral jelly nz cases linked to this cluster are being contacted and told they must isolate for 14 days, get tested, get another test if any symptoms develop and stay isolated for the full 14 days, even if a negative test result is received within this period. Among the new cases today, two are household contacts of cases linked to Liverpool Hospital. Prior to diagnosis many of the recently confirmed cases have attended a variety of locations and a full list of locations is available on the link below. New COVID-19 cases buy kamagra oral jelly nz have visited the following locations in Mosman, St Ives and Rosebery and people attending at the same time must monitor for symptoms, get tested immediately if they develop and stay isolated until a negative test result is received. Archie Bear café, Mosman Rowers - 24 August 11am to 12 noon and Tuesday 25 August 9:00am to 9.30am Rosebery Post Shop, 371 Gardeners Rd, Rosebery - 26 August 1:30pm-1:40pm St Ives Shopping Centre, 166 Mona Vale Rd, St Ives - 24 August 2:30pm-3:30 pm NSW Health is treating 67 COVID-19 cases, including six in intensive care and four who are ventilated.

85 per cent of cases being treated by NSW Health are in non-acute, out-of-hospital care. Due to the widening spread of the CBD cluster across multiple locations buy kamagra oral jelly nz in the Sydney and Central Coast, NSW Health is strongly advising people who live or work in these areas to not visit aged care facilities at this time. This is a precaution while the cluster is investigated, cases are identified and isolated and contact tracing is done. NSW Health will continue to closely monitor the number and location of cases in Sydney and the Central Coast and will adjust the advice regarding visitor restrictions on aged care facilities according to the level of local risk. NSW Health buy kamagra oral jelly nz will provide an update during http://sw.keimfarben.de/low-price-kamagra/ the next week.

COVID-19 continues to circulate in the community and we must all be vigilant. It is vital that people get a test as soon as buy kamagra oral jelly nz they develop symptoms. People should ensure that they stay at least 1.5m from others and that they wear a mask in situations - especially on public transport - where physical distancing is difficult. Locations linked to known cases, advice on testing and isolation, and areas identified for increased testing can be found at NSW Government - Latest new and updates.​ Anyone identified as a close contact and directed to undertake 14 days self-isolation must stay in isolation for the full 14 days, even if they test negative during this time. To help stop the spread of buy kamagra oral jelly nz COVID-19.

If you are unwell, stay in, get tested and isolate. Wash your hands regularly. Take hand sanitiser with you when you go buy kamagra oral jelly nz out.Keep your distance. Leave 1.5 metres between yourself and others.Wear a mask in situations where you cannot physically distance. A full list buy kamagra oral jelly nz of COVID-19 testing clinics is available or people can visit their GP.

Confirmed cases to date Overseas2,067Interstate acquired89Locally acquired – contact of a confirmed case and/or in a known cluster1,296Locally acquired – contact not identified391Under investigation​1 Counts reported for a particular day may vary over time with ongoing enhanced surveillance activities. Returned travellers in hotel quarantine to date​​ Symptomatic travellers tested4,765Found positive122 As​ymptomatic travellers screened at a day 217,750Found positive88 Asymptomatic travellers screened at a day 1030,788​Found positive119​Video update​​NSW Health is investigating new cases of COVID-19 in relation to City Tattersalls Fitness Centre on Pitt Street.These cases attended the centre during the past few days, while unknowingly infectious and after being exposed to infections in the gym.Anyone who attended this venue on the following dates and times are considered to be close contacts and must immediately get tested for COVID-19, and self-isolate for 14 days since their last visit. Wednesday 19 August between 8am - 2pm Friday 21 August between buy kamagra oral jelly nz 8am - 2pm, including. Aqua Aerobics from 10am-10:45am Stretch Class from 11am – 11:50am Pump Class from 12:15pm - 1pm Sunday 23 August between 8am - 2pm Monday 24 August between 8am - 2pm Tuesday 25 August between 8am - 2pm Members who attended the gym on the above dates but outside those times should be on the alert for symptoms and get tested and self-isolate if symptoms do develop.A previously reported case attended one of the gaming areas of City Tattersalls on 24 August. Others who were in the gaming areas on this day must monitor for symptoms and get tested immediately if even the mildest symptoms develop.

NSW Health is investigating whether the CBD cluster originated in the City Tattersalls Club and then spread to workplaces in the city and to households across Sydney and the Central buy kamagra oral jelly nz Coast. To assist in identifying undiagnosed earlier COVID cases, NSW Health is asking anyone who attended the Club between 4 August 2020 – 18 August 2020 to get tested for COVID-19 and isolate until a negative test result is received. A full list of COVID-19 testing clinics is available or people can visit their GP..

How to get a kamagra prescription from your doctor

NONE

We live in unprecedented http://sw.keimfarben.de/generic-kamagra-online-for-sale/ times how to get a kamagra prescription from your doctor. But what makes them without parallel is not the current pandemic crisis nor the continued problems facing minorities in our institutions. Rather, it’s that for the first time, the problems of accessibility, rights and freedoms are now how to get a kamagra prescription from your doctor invading privileged spaces. There can be no ‘getting back to normal’, because ‘normal’ only ever benefited the white, Western, patriarchal, abled and cis ideals.

For many, the world how to get a kamagra prescription from your doctor is not suddenly on fire. It has long been burning.The present pandemic lays bare systemic prejudice against the most vulnerable among us. We at Medical Humanities, with our focus on global health and social justice, welcome discussion about how the crisis has disproportionately affected racial and fiscal minorities, those from the disabled community, those who are LGBTQA+ and other vulnerable groups. What we focus on here, now, can lead to greater accessibility and equity in the future.In this expanded how to get a kamagra prescription from your doctor issue, we offer some of the incredible work being done across the field of medical humanities prior to the COVID-19 crisis, and we are already reviewing articles on the role of health humanities during the pandemic.

The process of academic publishing tends not to lend itself to immediacy, however, and the challenges of pandemic means greater pressure on everyone, from the authors to the reviewers and readers.To remedy this, we at Medical Humanities have been increasing the work on our blog platform, a place where content can be quickly updated, and where conversations can occur among readers and writers. We openly invite submissions concerning the virus, as well as topics relevant to our wider CFP (call how to get a kamagra prescription from your doctor for posts/papers) this year on social justice and health, to both blog and journal. We will do our best to expedite. Finally, we have also been addressing social justice and access in our podcast, where we interviewed disability activist Alice Wong and most recently Dr Oni Blackstock, primary care physician and HIV specialist in New York.

We hope how to get a kamagra prescription from your doctor to have many more on these critical subjects.We wish all of you good health and safety and know that many of you are yet on the front lines. Thank you for being part of the community of Medical Humanities.IntroductionMinecraft is a computer game with no specific goals to accomplish. The gameworld consists of three-dimensional (3D) cubes and objects which the player (Steve) can mine and build how to get a kamagra prescription from your doctor into infinitely complex (and logically impossible) structures. Steve sometimes encounters other characters (‘mobs’), such as animals and hostile creatures.

He can ‘spawn’ and destroy them. While it looks like a harmless game of logical construction, it conveys some worryingly delusive ideas about the how to get a kamagra prescription from your doctor real world. The difference between real and imagined structures is at the heart of the age-old debate around categorising mental disorders.Classification in mental health has had various forms throughout history. Mack and colleagues set out a history of psychiatric classification beginning in 2600 BC with Egyptian references to melancholia and hysteria how to get a kamagra prescription from your doctor.

Through the Ancient Greeks with Hippocrates’ phrenitis, mania, melancholia, epilepsy, hysteria and Scythian disease. Through the Renaissance period. Through to 19th-century psychiatry how to get a kamagra prescription from your doctor featuring Pinel (known as the first psychiatrist), Kraepelin (known for observational classification) and Freud (known for classifying neurosis and psychosis).1Although the history of psychiatric classification identifies some common trends such as the labels ‘melancholia’ and ‘hysteria’ which have survived millennia, the label ‘depression’ is relatively new. The earliest usage noted by Snaith is from 1899.

€˜in simple pathological depression…the patient exhibits a growing indifference to his former pursuits…’.2 Snaith noted that early 20th-century psychiatrists like Adolf Meyer hoped that ‘depression’ would come to encompass how to get a kamagra prescription from your doctor a broad category under which descriptions of subtypes would emerge. This did not happen until the middle of the 20th century. With the publication of the sixth International Classification of Diseases (ICD) in 1948 and the Diagnostic and Statistical Manual of Mental Disorders (DSM) in 1952 and their subsequent revisions, the latter half of the 20th century has seen depression subtype labels proliferate. In their study of the social determinants of diagnostic labels in depression, McPherson and Armstrong illustrate how the codification of depression subtypes in how to get a kamagra prescription from your doctor the latter half of the 20th century has been shaped by the evolving context of psychiatry, including power struggles within the profession, a move to community care and the development of psychopharmacology.3During this period, McPherson and Armstrong describe how subsequent versions of the DSM served as battlegrounds for professional disputes and philosophical quarrels around categorisation of mental disorders.

DSM I and DSM II have been described as products of an American Psychiatric Association dominated by psychoanalytic psychiatrists.4 DSM III and DSM III-R have been described as a radical rejection of psychoanalytic thinking, a ‘neo-Kraepelinian revolution’, a reference to the observational descriptive techniques of 19th-century psychiatrist Emil Kraepelin who classified mental disorders into two broad categories. €˜dementia praecox’ and ‘manic-depression’.5 DSM III was seen by some as a turning point in the use of the medical model of mental illness, through provision how to get a kamagra prescription from your doctor of specific inclusion and exclusion criteria, and use of field trials and a multiaxial system.6 These latter technocratic additions to psychiatric labelling served to engender a much closer alignment between psychiatry, science and medicine.The codification of mental disorders in manuals has been described by Thomas Schacht as intrinsic to the relationship between science and politics and the way in which psychiatrists gain significant social power by aligning themselves to science.7 His argument drew on Szasz, who saw the mental health establishment as a therapeutic state. Zimbardo, who described psychiatric care as a controlling force. And Foucault, who described the categorisation of the mentally ill as a force for isolating ‘the other’.

Diagnostic critique has been further developed through a cultural how to get a kamagra prescription from your doctor relativist lens in that what Western psychiatrists classify as a depression is constructed differently in other cultures.8 Considering these limitations, some critics have gone so far as to argue that psychiatric diagnostic systems should be abolished.9Yet architects of DSM manuals have worked hard to ensure the technology of classification is regarded as genuine scientific activity with sound roots in philosophy of science. In their philosophical defence of DSM IV, Allen Frances and colleagues address their critics under the headings ‘nominalism vs realism’, ‘empiricism vs rationalism’ and ‘categorical vs dimensional’.10 The implication is that there are opposing stances in which a choice must be made or a middle ground forged by those reasonable enough to recognise the need for pragmatism in the service of clinical utility. The nominalism–realism debate is illustrated using as metaphor three different stances a cricket how to get a kamagra prescription from your doctor umpire might take on calling strikes and balls. The discussion sets out two of these as extreme views.

€˜at one extreme…those who take a reductionistically realistic view of the world’ versus ‘the solipsistic nominalists…might content that nothing exists’. Szasz, who is how to get a kamagra prescription from your doctor characterised as holding particularly extreme views, is named as an archetypal solipsist. There is implied to be a degree of arrogance associated with this view in the illustrative example in which the umpire states ‘there are no balls and there are no strikes until I call them’. Frances therefore sets up a means of grouping two kinds of people as philosophical extremists who can be dismissed, while avoiding addressing the philosophical problems they pose.Frances provides little if any justification for the middle ground stance, ‘There are balls and there are strikes and I call them as I see them’, other than to focus on its clinical utility and the lack of clinical utility in the alternatives how to get a kamagra prescription from your doctor ‘naïve realism’ and ‘heuristically barren solipsism’.

The natural conclusion the reader is invited to reach is that a middle ground of a heuristic concept is naturally right because it is not extreme and is naturally useful clinically, without specifying in what way this stance is coherent, resolves the two alternatives, and in what way a heuristic construct that is not ‘real’ can be subject to scientific testing.Similarly, in discussing the ‘categorical vs dimensional’, Frances promotes the ‘prototype approach’. Those holding opposing views are labelled as ‘dualists’ or ‘dichotomisers’. The prototypical approach is again put how to get a kamagra prescription from your doctor forward as a clinically useful middle ground. Illustrations are drawn from natural science.

€˜a triangle and a square are never the same’, inciting the reader to consider science as how to get a kamagra prescription from your doctor value-free. The prototypical approach emerges as a natural solution, yet the authors do not address how a diagnostic prototype resolves the issues posed by the two alternatives, nor how a prototype can be subjected to natural science methods.The argument presented here is not a defence of solipsism or dualism. Rather it aims to illustrate that if for pragmatic purposes clinicians and policymakers choose to gloss over the philosophical flaws in classification practices, it is then risky to move beyond the heuristic and apply natural science methods to these constructs adding multiple layers of technocratic subclassification. Doing so is more how to get a kamagra prescription from your doctor like playing Minecraft than cricket.

The National Institute for Health and Care Excellence (NICE) guideline for depression is taken as an example of the philosophical errors that can follow from playing Minecraft with unsound heuristic devices, specifically subcategories of persistent forms of depression. As well how to get a kamagra prescription from your doctor as serving a clinical purpose, diagnosis in medicine is a way of allocating resources for insurance companies and constructing clinical guidelines, which in turn determine rationing within the National Health Service. The consequences for recipients of healthcare are therefore significant. Clinical utility is arguably not being served at all and patients are left at risk of poor-quality care.Heterogeneity of persistent depressionAndrea Jobst and colleagues note that ‘because of their chronic clinical course, approximately 40% of CD [chronic depression] patients also fulfil criteria for TRD [treatment resistant depression]…usually defined by the number of non-successful biological treatments’.11 This position is reflected in the DSM VAmerican Psychiatric Association (2013), the European Psychiatric Association (EPA) guidance and the ICD-11(World Health Organisation, 2018), which all use a ‘persistent’ depression category, acknowledging a loosely defined mixed group of long-term, difficult-to-treat depressive conditions, often associated with dysthymia and comorbid common mental disorders, various personality traits and psychosocial disability.In contrast, the NICE 2018 draft guideline separates treatments into those for ‘new episodes’ of depression.

€˜further-line’ treatment of depression (equivalent to TRD), CD and how to get a kamagra prescription from your doctor ‘depression with co-morbidities’. The latter is subdivided into treatments for ‘complex depression’ and ‘psychotic depression’. These categories and subcategories introduce an unfortunate sense of certainty as though these labels represent real how to get a kamagra prescription from your doctor things. An analysis follows of how these definitions play out in terms of grouping of randomised controlled trials in the NICE evidence review.

Specifically, the analysis reveals the overlap between populations in trials which have been separated into discrete categories, revealing significant limitations to the utility of the category labels.The NICE definition of CD requires trial samples to meet the criteria for major depressive disorder (MDD) for 2 years. Dysthymia and double depression (MDD superimposed on dysthymia) were included how to get a kamagra prescription from your doctor. If 75% of the trial population met these criteria, the trial was reviewed in the CD category.12 The definition of TRD (or ‘further-line treatments’) required that the trial sample had demonstrated a ‘limited response to previous treatment’ and randomised to the further-line treatment at this point. If 80% of the trial participants met these criteria, it was reviewed in the TRD category.13 Complex depression was defined as how to get a kamagra prescription from your doctor ‘depression co-existing with personality disorder’.

To be classed as complex, 51% of trial participants had to have personality disorder (PD).14It is immediately clear from these definitions that there is a potential problem with attempting to categorise trial populations into just one of these categories. These populations are likely to overlap, whether or not a trial protocol sets out to explicitly record all of this information. The analysis below will how to get a kamagra prescription from your doctor illustrate this using examples from within the NICE review.Cataloguing complexity in trial populationsWithin the category of further-line treatments (TRD), 64 trials were reviewed. Comparisons within these trials were further subcategorised into ‘dose escalation strategies’, ‘augmentation strategies’ and ‘switching strategies’.

In drilling down by way of illustration, this analysis considers the 51 trials in the augmentation how to get a kamagra prescription from your doctor strategy evidence review. Of these, two were classified by the reviewers as also fulfilling the criteria for CD but were not analysed in the CD category (Study IDs. Fonagy 2015 and Kocsis 200915). About half of the trials (23/51) did not report the mean duration of episode, meaning that it is how to get a kamagra prescription from your doctor not possible to know what percentage of participants also met the criteria for CD.

Of trials that did report episode duration, 17 reported a mean duration longer than 24 months. While the standard deviations varied in size or were unreported, the mean indicates a good likelihood that a significant proportion of the participants across how to get a kamagra prescription from your doctor these 51 trials met the criteria for CD.Details of baseline employment, trauma history, suicidality, physical comorbidity, axis I comorbidity and PD (all clinical indicators of complexity, severity and chronicity) were not collated by NICE. For the present analysis, all 51 publications were examined and data compiled concerning clinical complexity in the trial populations. Only 14 of 51 trials report employment data.

Of those that do, unemployment ranges from how to get a kamagra prescription from your doctor 12% to 56% across trial samples. None of the trials report trauma history. About half of the trials how to get a kamagra prescription from your doctor (26/51) excluded people who were considered a suicide risk. The others did not.A large proportion of trials (30/51) did not provide any data on axis 1 comorbidity.

Of these, 18 did not exclude any diagnoses, while 12 excluded some (but not all) disorders. The most common diagnoses excluded were psychotic disorders, substance or alcohol abuse, and bipolar disorder how to get a kamagra prescription from your doctor (excluded in 26, 25 and 23 trials, respectively). Only 7 of 51 trials clearly stated that all axis 1 diagnoses were excluded. This leaves how to get a kamagra prescription from your doctor only 13 studies providing any data about comorbidity.

Of these, 9 gave partial data on one or two conditions, while 4 reported either the mean number of disorders (range 1.96–2.9) or the percentage of participants (range 68.1–96.7) with any comorbid diagnosis (Nierenberg 2003a, Nierenberg 2006, Watkins 2011a, Town 201715).The majority of trials (46/51) did not report the prevalence of PD. Many stated PD as an exclusion criterion but without defining a threshold for exclusion. For example, PD could be excluded if it ‘impacted’ the depression, if it was ‘significant’, ‘severe’ or how to get a kamagra prescription from your doctor ‘persistent’. Some excluded certain PDs (such as antisocial or borderline) and not others but without reporting the prevalence of those not excluded.

In the five trials where prevalence was clear, prevalence ranged from 0% (Ravindran 2008a15), where all PDs were excluded, to how to get a kamagra prescription from your doctor 87.5% of the sample (Town 201715). Two studies reported the mean number of PDs. 2.0 (Nierenberg 2003a) and 0.85 (Watkins 2011a15).The majority of trials (43/51) did not report the prevalence of physical illness. Many stated illness as an exclusion criterion, but the definitions and thresholds were vague and could be interpreted in different how to get a kamagra prescription from your doctor ways.

For example, illness could be excluded kamagra nl opgelicht if it was ‘unstable’, ‘serious’, ‘significant’, ‘relevant’, or would ‘contraindicate’ or ‘impact’ the medication. Of the eight trials reporting information about physical health, there was a how to get a kamagra prescription from your doctor wide variation. Four reported prevalence varying from 7.6% having a disability (Eisendrath 201615) to 90.9% having an illness or disability (Town 201715). Four used scales of physical health.

Two indicating mild problems (Nierenberg 2006, Lavretsky 201115) and two indicating moderately high levels of illness (Thase 2007, how to get a kamagra prescription from your doctor Fang 201015).The NICE review also divided trial populations into a dichotomy of ‘more severe’ and ‘less severe’ on the grounds that this would be a clinically useful classification for general practitioners. NICE applied a bespoke methodology for creating this dichotomy, abandoning validated measure thresholds in order first to generate two ‘homogeneous’ groups to ‘facilitate analysis’, and second to create an algorithm to ‘read across’ different measures (such as the Beck Depression Inventory, the Hamilton Rating Scale for Depression (HRSD) and the Montgomery-Asberg Depression Rating Scale).16 Examining trials which use more than one of these measures reveals problems in the algorithm. Of the how to get a kamagra prescription from your doctor 51 trials, there are 6 instances in which the study population falls into NICE’s more severe category according to one measure and into the less severe category according to another. In four of these trials, NICE chose the less severe category (Souza 2016, Watkins 2011a, Fonagy 2015, Town 201715).

The other two trials were designated more severe (Barbee 2011, Dunner 200715). Only 17 of 51 how to get a kamagra prescription from your doctor trials reported two or more depression scale measures, leaving much unknown about whether other study populations could count as both more severe and less severe.Absence of knowledge or knowledge of absence?. A key philosophical error in science is to confuse an absence of knowledge with knowledge of absence. It is likely that some of the study populations deemed lacking in how to get a kamagra prescription from your doctor complexity or severity could actually have high degrees of complexity and/or severity.

Data to demonstrate this may either fall foul of a guideline committee decision to prioritise certain information over other conflicting information (as in the severity algorithm). The information may be non-existent as it was not collected. It may be somewhere in the publication pipeline how to get a kamagra prescription from your doctor. Or it may be sitting in a database with a research team that has run out of funds for supplementary analyses.

Wherever those data are or are not, their how to get a kamagra prescription from your doctor absence from published articles does not define the phenomenology of depression for the patients who took part. As a case in point, data from the Fonagy 2015 trial presented at conferences but not published reveal that PD prevalence data would place the trial well within the NICE complex depression category, and that the sample had high levels of past trauma and physical condition comorbidity. The trial also meets the guideline criteria for CD according to the guideline’s own appendices.17 Reported axis 1 comorbidity was high (75.2% had anxiety disorder, 18.6% had substance abuse disorder, 13.2% had eating disorder).18 The mean depression scores at baseline were 36.5 on the Beck Depression Inventory and 20.1 on the HRSD (severe and very severe, respectively, according to published cut-off scores). NICE categorised this population as less severe TRD, not CD how to get a kamagra prescription from your doctor and not complex.Notes1.

Avram H. Mack et how to get a kamagra prescription from your doctor al. (1994), “A Brief History of Psychiatric Classification. From the Ancients to DSM-IV,” Psychiatric Clinics 17, no.

Snaith (1987), “The Concepts of Mild Depression,” British Journal of Psychiatry 150, no. 3. 387.3. Susan McPherson and David Armstrong (2006), “Social Determinants of Diagnostic Labels in Depression,” Social Science &.

Grob (1991), “Origins of DSM-I. A Study in Appearance and Reality,” The American Journal of Psychiatry. 421–31.5. Wilson M.

Compton and Samuel B. Guze (1995), “The Neo-Kraepelinian Revolution in Psychiatric Diagnosis,” European Archives of Psychiatry and Clinical Neuroscience 245, no. 4. 198–9.6.

Gerald L. Klerman (1984), “A Debate on DSM-III. The Advantages of DSM-III,” The American Journal of Psychiatry. 539–42.7.

Thomas E. Schacht (1985), “DSM-III and the Politics of Truth,” American Psychologist. 513–5.8. Daniel F.

Hartner and Kari L. Theurer (2018), “Psychiatry Should Not Seek Mechanisms of Disorder,” Journal of Theoretical and Philosophical Psychology 38, no. 4. 189–204.9.

Sami Timimi (2014), “No More Psychiatric Labels. Why Formal Psychiatric Diagnostic Systems Should Be Abolished,” Journal of Clinical and Health Psychology 14, no. 3. 208–15.10.

Allen Frances et al. (1994), “DSM-IV Meets Philosophy,” The Journal of Medicine and Philosophy. A Forum for Bioethics and Philosophy of Medicine 19, no. 3.

207–18.11. Andrea Jobst et al. (2016), “European Psychiatric Association Guidance on Psychotherapy in Chronic Depression Across Europe,” European Psychiatry 33. 20.12.

National Institute for Health and Care Excellence (2018), Depression in Adults. Treatment and Management. Draft for Consultation, https://www.nice.org.uk/guidance/gid-cgwave0725/documents/full-guideline-updated, 507.13. Ibid., 351–62.14.

Ibid., 597.15. Note that in order to refer to specific trials reviewed in the guideline, rather than the full citation, the Study IDs from column A in appendix J5 have been used. See www.nice.org.uk/guidance/gid-cgwave0725/documents/addendum-appendix-9 for details and full references.16. National Institute for Health and Care Excellence (2018), Depression in Adults.

Treatment and Management. Second Consultation on Draft Guideline – Stakeholder Comments Table, https://www.nice.org.uk/guidance/gid-cgwave0725/documents/consultation-comments-and-responses-2, 420–1.17. National Institute for Health and Care Excellence (2018), Depression in Adults, appendix J5.18. Peter Fonagy et al.

(2015), “Pragmatic Randomized Controlled Trial of Long-Term Psychoanalytic Psychotherapy for Treatment-Resistant Depression. The Tavistock Adult Depression Study (TADS),” World Psychiatry 14, no. 3. 312–21.19.

American Psychological Association (2018), Clinical Practice Guideline for the Treatment of Depression in Children, Adolescents, and Young, Middle-aged, and Older Adults. Draft.20. Jacqui Thornton (2018), “Depression in Adults. Campaigners and Doctors Demand Full Revision of NICE Guidance,” BMJ 361.

We live buy kamagra oral jelly nz in unprecedented times. But what makes them without parallel is not the current pandemic crisis nor the continued problems facing minorities in our institutions. Rather, it’s that for the first time, the problems of accessibility, rights and freedoms are now buy kamagra oral jelly nz invading privileged spaces. There can be no ‘getting back to normal’, because ‘normal’ only ever benefited the white, Western, patriarchal, abled and cis ideals. For many, buy kamagra oral jelly nz the world is not suddenly on fire.

It has long been burning.The present pandemic lays bare systemic prejudice against the most vulnerable among us. We at Medical Humanities, with our focus on global health and social justice, welcome discussion about how the crisis has disproportionately affected racial and fiscal minorities, those from the disabled community, those who are LGBTQA+ and other vulnerable groups. What we focus on here, now, can lead to greater accessibility and equity in the future.In this expanded issue, we offer some of the incredible work being done across the field of medical humanities buy kamagra oral jelly nz prior to the COVID-19 crisis, and we are already reviewing articles on the role of health humanities during the pandemic. The process of academic publishing tends not to lend itself to immediacy, however, and the challenges of pandemic means greater pressure on everyone, from the authors to the reviewers and readers.To remedy this, we at Medical Humanities have been increasing the work on our blog platform, a place where content can be quickly updated, and where conversations can occur among readers and writers. We openly invite buy kamagra oral jelly nz submissions concerning the virus, as well as topics relevant to our wider CFP (call for posts/papers) this year on social justice and health, to both blog and journal.

We will do our best to expedite. Finally, we have also been addressing social justice and access in our podcast, where we interviewed disability activist Alice Wong and most recently Dr Oni Blackstock, primary care physician and HIV specialist in New York. We hope to have many more on these critical subjects.We wish all of you good health and safety and know that buy kamagra oral jelly nz many of you are yet on the front lines. Thank you for being part of the community of Medical Humanities.IntroductionMinecraft is a computer game with no specific goals to accomplish. The gameworld consists of three-dimensional (3D) cubes and buy kamagra oral jelly nz objects which the player (Steve) can mine and build into infinitely complex (and logically impossible) structures.

Steve sometimes encounters other characters (‘mobs’), such as animals and hostile creatures. He can ‘spawn’ and destroy them. While it looks like a harmless game of logical construction, it conveys some buy kamagra oral jelly nz worryingly delusive ideas about the real world. The difference between real and imagined structures is at the heart of the age-old debate around categorising mental disorders.Classification in mental health has had various forms throughout history. Mack and colleagues set out a history of psychiatric classification beginning in 2600 BC with Egyptian references to melancholia buy kamagra oral jelly nz and hysteria.

Through the Ancient Greeks with Hippocrates’ phrenitis, mania, melancholia, epilepsy, hysteria and Scythian disease. Through the Renaissance period. Through to 19th-century psychiatry featuring Pinel (known as the first psychiatrist), Kraepelin (known for observational classification) and Freud (known for classifying neurosis and psychosis).1Although the history of psychiatric classification buy kamagra oral jelly nz identifies some common trends such as the labels ‘melancholia’ and ‘hysteria’ which have survived millennia, the label ‘depression’ is relatively new. The earliest usage noted by Snaith is from 1899. €˜in simple pathological depression…the patient exhibits a growing indifference to his former pursuits…’.2 Snaith noted that early 20th-century psychiatrists buy kamagra oral jelly nz like Adolf Meyer hoped that ‘depression’ would come to encompass a broad category under which descriptions of subtypes would emerge.

This did not happen until the middle of the 20th century. With the publication of the sixth International Classification of Diseases (ICD) in 1948 and the Diagnostic and Statistical Manual of Mental Disorders (DSM) in 1952 and their subsequent revisions, the latter half of the 20th century has seen depression subtype labels proliferate. In their study of the social determinants of diagnostic labels in depression, McPherson and Armstrong illustrate how the codification of depression subtypes in the latter half of the 20th century has been shaped by the evolving context of psychiatry, including power struggles within the profession, a move buy kamagra oral jelly nz to community care and the development of psychopharmacology.3During this period, McPherson and Armstrong describe how subsequent versions of the DSM served as battlegrounds for professional disputes and philosophical quarrels around categorisation of mental disorders. DSM I and DSM II have been described as products of an American Psychiatric Association dominated by psychoanalytic psychiatrists.4 DSM III and DSM III-R have been described as a radical rejection of psychoanalytic thinking, a ‘neo-Kraepelinian revolution’, a reference to the observational descriptive techniques of 19th-century psychiatrist Emil Kraepelin who classified mental disorders into two broad categories. €˜dementia praecox’ and ‘manic-depression’.5 DSM III was seen by some as a turning point in the use of the medical model of mental illness, through provision of specific inclusion and exclusion criteria, and use of field trials and a multiaxial system.6 These latter technocratic additions to psychiatric labelling served to engender a much closer alignment between psychiatry, science and medicine.The codification of mental disorders in manuals has been described by Thomas Schacht as intrinsic to the relationship between science and politics and the way in which psychiatrists gain significant social power by aligning themselves to science.7 His argument drew on Szasz, who saw the mental health establishment buy kamagra oral jelly nz as a therapeutic state.

Zimbardo, who described psychiatric care as a controlling force. And Foucault, who described the categorisation of the mentally ill as a force for isolating ‘the other’. Diagnostic critique has been further developed through a cultural relativist lens in that what buy kamagra oral jelly nz Western psychiatrists classify as a depression is constructed differently in other cultures.8 Considering these limitations, some critics have gone so far as to argue that psychiatric diagnostic systems should be abolished.9Yet architects of DSM manuals have worked hard to ensure the technology of classification is regarded as genuine scientific activity with sound roots in philosophy of science. In their philosophical defence of DSM IV, Allen Frances and colleagues address their critics under the headings ‘nominalism vs realism’, ‘empiricism vs rationalism’ and ‘categorical vs dimensional’.10 The implication is that there are opposing stances in which a choice must be made or a middle ground forged by those reasonable enough to recognise the need for pragmatism in the service of clinical utility. The nominalism–realism debate is illustrated using as metaphor three different stances buy kamagra oral jelly nz a cricket umpire might take on calling strikes and balls.

The discussion sets out two of these as extreme views. €˜at one extreme…those who take a reductionistically realistic view of the world’ versus ‘the solipsistic nominalists…might content that nothing exists’. Szasz, who buy kamagra oral jelly nz is characterised as holding particularly extreme views, is named as an archetypal solipsist. There is implied to be a degree of arrogance associated with this view in the illustrative example in which the umpire states ‘there are no balls and there are no strikes until I call them’. Frances therefore sets up a means of grouping two kinds of people as philosophical extremists who can be dismissed, while avoiding addressing the philosophical problems they pose.Frances provides little if any justification for the middle ground stance, ‘There are balls and there are strikes and I call them as I see them’, other buy kamagra oral jelly nz than to focus on its clinical utility and the lack of clinical utility in the alternatives ‘naïve realism’ and ‘heuristically barren solipsism’.

The natural conclusion the reader is invited to reach is that a middle ground of a heuristic concept is naturally right because it is not extreme and is naturally useful clinically, without specifying in what way this stance is coherent, resolves the two alternatives, and in what way a heuristic construct that is not ‘real’ can be subject to scientific testing.Similarly, in discussing the ‘categorical vs dimensional’, Frances promotes the ‘prototype approach’. Those holding opposing views are labelled as ‘dualists’ or ‘dichotomisers’. The prototypical approach is again buy kamagra oral jelly nz put forward as a clinically useful middle ground. Illustrations are drawn from natural science. €˜a triangle and a square are never the same’, inciting the reader to consider science as buy kamagra oral jelly nz value-free.

The prototypical approach emerges as a natural solution, yet the authors do not address how a diagnostic prototype resolves the issues posed by the two alternatives, nor how a prototype can be subjected to natural science methods.The argument presented here is not a defence of solipsism or dualism. Rather it aims to illustrate that if for pragmatic purposes clinicians and policymakers choose to gloss over the philosophical flaws in classification practices, it is then risky to move beyond the heuristic and apply natural science methods to these constructs adding multiple layers of technocratic subclassification. Doing so is more buy kamagra oral jelly nz like playing Minecraft than cricket. The National Institute for Health and Care Excellence (NICE) guideline for depression is taken as an example of the philosophical errors that can follow from playing Minecraft with unsound heuristic devices, specifically subcategories of persistent forms of depression. As well as serving a clinical purpose, diagnosis in medicine is a way of allocating resources for insurance companies and constructing clinical guidelines, which in turn determine rationing within the National Health buy kamagra oral jelly nz Service.

The consequences for recipients of healthcare are therefore significant. Clinical utility is arguably not being served at all and patients are left at risk of poor-quality care.Heterogeneity of persistent depressionAndrea Jobst and colleagues note that ‘because of their chronic clinical course, approximately 40% of CD [chronic depression] patients also fulfil criteria for TRD [treatment resistant depression]…usually defined by the number of non-successful biological treatments’.11 This position is reflected in the DSM VAmerican Psychiatric Association (2013), the European Psychiatric Association (EPA) guidance and the ICD-11(World Health Organisation, 2018), which all use a ‘persistent’ depression category, acknowledging a loosely defined mixed group of long-term, difficult-to-treat depressive conditions, often associated with dysthymia and comorbid common mental disorders, various personality traits and psychosocial disability.In contrast, the NICE 2018 draft guideline separates treatments into those for ‘new episodes’ of depression. €˜further-line’ treatment of depression (equivalent to TRD), CD and ‘depression with co-morbidities’ buy kamagra oral jelly nz. The latter is subdivided into treatments for ‘complex depression’ and ‘psychotic depression’. These categories and subcategories introduce an unfortunate sense of certainty buy kamagra oral jelly nz as though these labels represent real things.

An analysis follows of how these definitions play out in terms of grouping of randomised controlled trials in the NICE evidence review. Specifically, the analysis reveals the overlap between populations in trials which have been separated into discrete categories, revealing significant limitations to the utility of the category labels.The NICE definition of CD requires trial samples to meet the criteria for major depressive disorder (MDD) for 2 years. Dysthymia and buy kamagra oral jelly nz double depression (MDD superimposed on dysthymia) were included. If 75% of the trial population met these criteria, the trial was reviewed in the CD category.12 The definition of TRD (or ‘further-line treatments’) required that the trial sample had demonstrated a ‘limited response to previous treatment’ and randomised to the further-line treatment at this point. If 80% of the trial participants met these criteria, it was reviewed in the TRD category.13 buy kamagra oral jelly nz Complex depression was defined as ‘depression co-existing with personality disorder’.

To be classed as complex, 51% of trial participants had to have personality disorder (PD).14It is immediately clear from these definitions that there is a potential problem with attempting to categorise trial populations into just one of these categories. These populations are likely to overlap, whether or not a trial protocol sets out to explicitly record all of this information. The analysis below will illustrate this using examples from within the NICE review.Cataloguing complexity in trial populationsWithin buy kamagra oral jelly nz the category of further-line treatments (TRD), 64 trials were reviewed. Comparisons within these trials were further subcategorised into ‘dose escalation strategies’, ‘augmentation strategies’ and ‘switching strategies’. In drilling down by way of illustration, this analysis considers the buy kamagra oral jelly nz 51 trials in the augmentation strategy evidence review.

Of these, two were classified by the reviewers as also fulfilling the criteria for CD but were not analysed in the CD category (Study IDs. Fonagy 2015 and Kocsis 200915). About half of the trials (23/51) did not report the mean duration of episode, buy kamagra oral jelly nz meaning that it is not possible to know what percentage of participants also met the criteria for CD. Of trials that did report episode duration, 17 reported a mean duration longer than 24 months. While the standard deviations varied in size or were unreported, the mean indicates a good likelihood that a buy kamagra oral jelly nz significant proportion of the participants across these 51 trials met the criteria for CD.Details of baseline employment, trauma history, suicidality, physical comorbidity, axis I comorbidity and PD (all clinical indicators of complexity, severity and chronicity) were not collated by NICE.

For the present analysis, all 51 publications were examined and data compiled concerning clinical complexity in the trial populations. Only 14 of 51 trials report employment data. Of those that do, unemployment ranges from 12% to 56% across buy kamagra oral jelly nz trial samples. None of the trials report trauma history. About half of the trials (26/51) excluded people who were considered buy kamagra oral jelly nz a suicide risk.

The others did not.A large proportion of trials (30/51) did not provide any data on axis 1 comorbidity. Of these, 18 did not exclude any diagnoses, while 12 excluded some (but not all) disorders. The most common diagnoses buy kamagra oral jelly nz excluded were psychotic disorders, substance or alcohol abuse, and bipolar disorder (excluded in 26, 25 and 23 trials, respectively). Only 7 of 51 trials clearly stated that all axis 1 diagnoses were excluded. This leaves only 13 studies buy kamagra oral jelly nz providing any data about comorbidity.

Of these, 9 gave partial data on one or two conditions, while 4 reported either the mean number of disorders (range 1.96–2.9) or the percentage of participants (range 68.1–96.7) with any comorbid diagnosis (Nierenberg 2003a, Nierenberg 2006, Watkins 2011a, Town 201715).The majority of trials (46/51) did not report the prevalence of PD. Many stated PD as an exclusion criterion but without defining a threshold for exclusion. For example, PD could be excluded if it ‘impacted’ the depression, if buy kamagra oral jelly nz it was ‘significant’, ‘severe’ or ‘persistent’. Some excluded certain PDs (such as antisocial or borderline) and not others but without reporting the prevalence of those not excluded. In the five trials where prevalence buy kamagra oral jelly nz was clear, prevalence ranged from 0% (Ravindran 2008a15), where all PDs were excluded, to 87.5% of the sample (Town 201715).

Two studies reported the mean number of PDs. 2.0 (Nierenberg 2003a) and 0.85 (Watkins 2011a15).The majority of trials (43/51) did not report the prevalence of physical illness. Many stated illness as buy kamagra oral jelly nz an exclusion criterion, but the definitions and thresholds were vague and could be interpreted in different ways. For example, illness could be excluded if it was ‘unstable’, ‘serious’, ‘significant’, ‘relevant’, or would ‘contraindicate’ or ‘impact’ the medication. Of the eight buy kamagra oral jelly nz trials reporting information about physical health, there was a wide variation.

Four reported prevalence varying from 7.6% having a disability (Eisendrath 201615) to 90.9% having an illness or disability (Town 201715). Four used scales of physical health. Two indicating mild problems (Nierenberg 2006, Lavretsky 201115) and two indicating moderately high levels of illness (Thase 2007, Fang 201015).The NICE review also divided trial populations into a dichotomy of ‘more severe’ and buy kamagra oral jelly nz ‘less severe’ on the grounds that this would be a clinically useful classification for general practitioners. NICE applied a bespoke methodology for creating this dichotomy, abandoning validated measure thresholds in order first to generate two ‘homogeneous’ groups to ‘facilitate analysis’, and second to create an algorithm to ‘read across’ different measures (such as the Beck Depression Inventory, the Hamilton Rating Scale for Depression (HRSD) and the Montgomery-Asberg Depression Rating Scale).16 Examining trials which use more than one of these measures reveals problems in the algorithm. Of the 51 trials, there are 6 instances in which the study population falls into NICE’s more severe category according to one measure and into buy kamagra oral jelly nz the less severe category according to another.

In four of these trials, NICE chose the less severe category (Souza 2016, Watkins 2011a, Fonagy 2015, Town 201715). The other two trials were designated more severe (Barbee 2011, Dunner 200715). Only 17 of 51 trials reported two or buy kamagra oral jelly nz more depression scale measures, leaving much unknown about whether other study populations could count as both more severe and less severe.Absence of knowledge or knowledge of absence?. A key philosophical error in science is to confuse an absence of knowledge with knowledge of absence. It is likely that some of buy kamagra oral jelly nz the study populations deemed lacking in complexity or severity could actually have high degrees of complexity and/or severity.

Data to demonstrate this may either fall foul of a guideline committee decision to prioritise certain information over other conflicting information (as in the severity algorithm). The information may be non-existent as it was not collected. It may be somewhere buy kamagra oral jelly nz in the publication pipeline. Or it may be sitting in a database with a research team that has run out of funds for supplementary analyses. Wherever those data are or are not, their absence from published articles does not define the buy kamagra oral jelly nz phenomenology of depression for the patients who took part.

As a case in point, data from the Fonagy 2015 trial presented at conferences but not published reveal that PD prevalence data would place the trial well within the NICE complex depression category, and that the sample had high levels of past trauma and physical condition comorbidity. The trial also meets the guideline criteria for CD according to the guideline’s own appendices.17 Reported axis 1 comorbidity was high (75.2% had anxiety disorder, 18.6% had substance abuse disorder, 13.2% had eating disorder).18 The mean depression scores at baseline were 36.5 on the Beck Depression Inventory and 20.1 on the HRSD (severe and very severe, respectively, according to published cut-off scores). NICE categorised this buy kamagra oral jelly nz population as less severe TRD, not CD and not complex.Notes1. Avram H. Mack et buy kamagra oral jelly nz al.

(1994), “A Brief History of Psychiatric Classification. From the Ancients to DSM-IV,” Psychiatric Clinics 17, no. 3. 515–9.2. R.

P. Snaith (1987), “The Concepts of Mild Depression,” British Journal of Psychiatry 150, no. 3. 387.3. Susan McPherson and David Armstrong (2006), “Social Determinants of Diagnostic Labels in Depression,” Social Science &.

Medicine 62, no. 1. 52–7.4. Gerald N. Grob (1991), “Origins of DSM-I.

A Study in Appearance and Reality,” The American Journal of Psychiatry. 421–31.5. Wilson M. Compton and Samuel B. Guze (1995), “The Neo-Kraepelinian Revolution in Psychiatric Diagnosis,” European Archives of Psychiatry and Clinical Neuroscience 245, no.

4. 198–9.6. Gerald L. Klerman (1984), “A Debate on DSM-III. The Advantages of DSM-III,” The American Journal of Psychiatry.

539–42.7. Thomas E. Schacht (1985), “DSM-III and the Politics of Truth,” American Psychologist. 513–5.8. Daniel F.

Hartner and Kari L. Theurer (2018), “Psychiatry Should Not Seek Mechanisms of Disorder,” Journal of Theoretical and Philosophical Psychology 38, no. 4. 189–204.9. Sami Timimi (2014), “No More Psychiatric Labels.

Why Formal Psychiatric Diagnostic Systems Should Be Abolished,” Journal of Clinical and Health Psychology 14, no. 3. 208–15.10. Allen Frances et al. (1994), “DSM-IV Meets Philosophy,” The Journal of Medicine and Philosophy.

A Forum for Bioethics and Philosophy of Medicine 19, no. 3. 207–18.11. Andrea Jobst et al. (2016), “European Psychiatric Association Guidance on Psychotherapy in Chronic Depression Across Europe,” European Psychiatry 33.

20.12. National Institute for Health and Care Excellence (2018), Depression in Adults. Treatment and Management. Draft for Consultation, https://www.nice.org.uk/guidance/gid-cgwave0725/documents/full-guideline-updated, 507.13. Ibid., 351–62.14.

Ibid., 597.15. Note that in order to refer to specific trials reviewed in the guideline, rather than the full citation, the Study IDs from column A in appendix J5 have been used. See www.nice.org.uk/guidance/gid-cgwave0725/documents/addendum-appendix-9 for details and full references.16. National Institute for Health and Care Excellence (2018), Depression in Adults. Treatment and Management.

Second Consultation on Draft Guideline – Stakeholder Comments Table, https://www.nice.org.uk/guidance/gid-cgwave0725/documents/consultation-comments-and-responses-2, 420–1.17. National Institute for Health and Care Excellence (2018), Depression in Adults, appendix J5.18. Peter Fonagy et al. (2015), “Pragmatic Randomized Controlled Trial of Long-Term Psychoanalytic Psychotherapy for Treatment-Resistant Depression. The Tavistock Adult Depression Study (TADS),” World Psychiatry 14, no.

3. 312–21.19. American Psychological Association (2018), Clinical Practice Guideline for the Treatment of Depression in Children, Adolescents, and Young, Middle-aged, and Older Adults. Draft.20. Jacqui Thornton (2018), “Depression in Adults.

Campaigners and Doctors Demand Full Revision of NICE Guidance,” BMJ 361. K2681..

Buy kamagra oral jelly usa

NONE

In 2003, severe acute respiratory syndrome (SARS) spread through 26 countries, infecting at least http://sw.keimfarben.de/kamagra-for-sale/ 8098 and causing at least 774 deaths (a case buy kamagra oral jelly usa fatality rate of 9.6%). Middle East respiratory syndrome (MERS) by January 2020 caused 2519 cases and 866 deaths (a case fatality rate of 34%). SARS and MERS are coronaviruses and both are not buy kamagra oral jelly usa as easily transmitted as COVID-19 because they require close contact with those infected (or also with camels in the case of MERS), and infected humans tend not to transmit before they have symptoms. Transmission of both mostly occurred within healthcare settings and could be controlled by improving infection control in hospitals.In 2015, Bill Gates in a TED lecture warned that we were more at risk of a global pandemic (he thought it would be influenza) than we were from nuclear war.COVID-19 probably first entered the human population in China in November 2019 in Wuhan and was first identified as such in December 2019. It spreads easily with a R0 (basic reproduction number) that represents the average number of people the average infected person would infect being between 1.5 and 3.5, depending on the surrounding circumstances.

While a large proportion of infections are asymptomatic, there is a significant mortality buy kamagra oral jelly usa rate (about 3.4% worldwide). Survival rates are worse in the elderly, in men and in those with comorbidities. There are no suitable mammal models to study.Because there is a significant proportion of asymptomatic infectious people, monitoring of epidemics necessitates screening to determine (1) the proportion of the population that is actively infected and or (2) the total number of those who have been infected. Both require buy kamagra oral jelly usa screening. To gain significant data, then whole populations or representative samples have to be tested.

In many circumstances, only those with high probability are buy kamagra oral jelly usa tested.DNA polymerase techniques on throat swabs (notably real-time reverse transcription PCR) can identify the actively infected, but such tests will need to be repeated, especially in healthcare staff who are both at increased risk of infection and could provide an increased risk of infection to their contacts.Antibody tests in theory can reveal who has been infected. However, such tests may not provide 100% reliable results, including the fact that their sensitivity will vary according to how common the infection is. If an infection is common, then a very sensitive test will identify all those infected and also a small number of false positives, but when the infection becomes less common, then the proportion of false positives will rise and a positive test could become less useful. Moreover, for how long would the buy kamagra oral jelly usa antibody-person be immune?. Counting the number of hospital deaths attributed to COVID-19 may be a guide to an epidemic, but deaths may be difficult to count in the community.

In any case, changes in death numbers usually lag a few weeks behind the time of infection.Would a lower infecting dose cause the following illness to be less severe?. Does the virus need several extra doubling times to exert its effects such that in this gained time host responses will be in a better position to combat the infection in high-risk groups or in buy kamagra oral jelly usa groups where medical care is minimal?. Could low-dose vaccination with COVID-19 itself be useful?. Shakespeare’s Hamlet (not an epidemiologist) suggested, ‘Diseases desperate grown, By desperate appliance are relieved, Or not at all’.All the aforementioned are key questions, the answers to many of which are not known at the time of writing and, even if they were, the answers might change with the passage of time.Various countries have made various policy choicesAt the time of writing (April 2020), COVID-19 has probably been in the human population for only about 6 months. In most countries, there are concerns about how the epidemic was initially handled, and buy kamagra oral jelly usa it is possible to predict some damming retrospective judgements.

However, we should concentrate on where we are, not where we might have been. Recriminations should wait.Many important decisions have to be made based on buy kamagra oral jelly usa incomplete information. Most COVID-19 decisions have to be made on speculations (guesswork and wishful thinking), on hypotheses (propositions made as a basis for reasoning, without an assumption of its truth) or on theories (suppositions or systems of ideas explaining something based on general principles). All COVID-19 decisions have to be made at the time ‘We have to start from where we are’ guided by the experiences of other countries that are ahead of us in the epidemic.Pandemics usually reveal inequalities and the poor, or those in unstable employment or in crowded accommodation, or with underlying health issues, or where healthcare is less affordable, or are in the less well educated will suffer the most. They will also comply buy kamagra oral jelly usa less with restrictions.

Ideologies, power blocks, leaders, social cohesion beliefs, the relevance of centralised or regional decision making, the abilities of popularism (political doctrines chosen to appeal to a majority of the electorate), welfare states (usually capitalist nations that recognise that food, shelter, education and medicine are basic rights to be ensured by government actions) and authoritarianism are all being stress tested by COVID-19. In the future, it will be interesting to judge how these societal systems played out when confronting the conflicting requirement to reconcile conflicting priorities of health and economic factors that involve conflicts between responding and planning for deaths (‘How should we cope with these’) and actually planning deaths. €˜We will have to accept that we will cause deaths whatever policy we adopt’.There is only one initial response to COVID-19 that reduces buy kamagra oral jelly usa infection rates and death rates. Dramatic quarantine ‘total lockdown’ measures. Some countries, including China, South Korea, Hong Kong, Taiwan and Singapore, hit the epidemic hard and early with lockdown quarantine to reduce the epidemic buy kamagra oral jelly usa.

Such countries perhaps tend towards acceptance of authoritarianism and their citizens less rebellious than in other countries. New Zealand did similarly. I could not possibly buy kamagra oral jelly usa comment on the US responses. However, on what criteria and at what speed should liberalisation of quarantine measure occur to avoid re-emergences?. There are in theory three final paths out of the COVID-19 crisis:First, a vaccine.

Even a perfect vaccine would buy kamagra oral jelly usa be difficult to evaluate with changing risks in the community. How protective would a vaccine be and for how long would it be effective?. Second, the identification of a treatment, either preventative or curative, so that the disease becomes a considerably less worrisome prospect even for those with comorbidities.Third, herd immunity, when enough of the population has acquired and survived COVID-19 and thus developed immunity with the infection persisting at a low level. Currently the only, not entirely definitive, way of estimating this is by measuring antibodies such that there would not be enough opportunities for disease transmission for the virus to continue circulating through populations with an Ro of less than 1, but the risk would not disappear buy kamagra oral jelly usa entirely. Moreover, how should immunity be monitored if antibody testing may not reflect herd immunity?.

Allowing herd immunity to develop initially would result in a huge spike in hospitalisations and deaths that could overwhelm most healthcare services, and that is why flattening such buy kamagra oral jelly usa spikes by quarantine was indicated. With flattening, there would still be illness and deaths but at a controlled slower rate and hopefully also smaller numbers, such that healthcare services could cope.There is a lot of opinion and numerous contributions by official and unofficial organisations and individuals who think their “single issue advice” should be followed. No one individual has the expertise required for management of all the complexities. Committees are required, including microbiologists, infectious diseases doctors, public health doctors, buy kamagra oral jelly usa epidemiologists, hospital and general practice representatives, epidemic mathematical modellers and economic advisers. Politicians have the responsibility to deliver decisions when, especially when, information is imperfect.

How many people would be infected if we did nothing?. What would the epidemic curve look buy kamagra oral jelly usa like in various situations?. What proportion of those infected would infect others in various situations?. How many of which population groups would require what extra healthcare services in various situations?. What would buy kamagra oral jelly usa be the effect of various measures at various times?.

What economic impacts might there be when these in themselves affect mortality rates?. I predict that COVID-19 will cause two buy kamagra oral jelly usa significant changes in political thought. First, it has to be realised that globalisation of such epidemics, and there will be more to come, will demand an integrated globalised response. Second, in 1987, Margaret Thatcher, the UK Prime Minister, said that ‘There is no such thing as society… the quality of our lives will depend on how much each of us is prepared to take responsibility for ourselves and each of us prepared to turn round and help by our own efforts those who are unfortunate’. The current UK Prime Minister in March 2020 presented a new synthesis, ‘There really is such a thing as society’.Finally, it is important to realise that everyone, no matter where they are, buy kamagra oral jelly usa for better or worse, has to rely on their existing rulers or governments.In 2003, severe acute respiratory syndrome (SARS) spread through 26 countries, infecting at least 8098 and causing at least 774 deaths (a case fatality rate of 9.6%) see it here.

Middle East respiratory syndrome (MERS) by January 2020 caused 2519 cases and 866 deaths (a case fatality rate of 34%). SARS and MERS are coronaviruses and both are not as easily transmitted as COVID-19 because they require close contact with those infected (or also with camels in the case of MERS), and infected humans tend not to transmit before they have symptoms. Transmission of both mostly occurred within healthcare settings and could be controlled by improving infection control in hospitals.In 2015, Bill Gates in a TED lecture warned that we were more at risk of a buy kamagra oral jelly usa global pandemic (he thought it would be influenza) than we were from nuclear war.COVID-19 probably first entered the human population in China in November 2019 in Wuhan and was first identified as such in December 2019. It spreads easily with a R0 (basic reproduction number) that represents the average number of people the average infected person would infect being between 1.5 and 3.5, depending on the surrounding circumstances. While a buy kamagra oral jelly usa large proportion of infections are asymptomatic, there is a significant mortality rate (about 3.4% worldwide).

Survival rates are worse in the elderly, in men and in those with comorbidities. There are no suitable mammal models to study.Because there is a significant proportion of asymptomatic infectious people, monitoring of epidemics necessitates screening to determine (1) the proportion of the population that is actively infected and or (2) the total number of those who have been infected. Both require buy kamagra oral jelly usa screening. To gain significant data, then whole populations or representative samples have to be tested. In many circumstances, only those with high probability are tested.DNA polymerase techniques on throat swabs (notably real-time reverse transcription PCR) can identify the actively infected, but such tests will need to be repeated, especially in healthcare staff who are both at increased risk of infection and could provide an increased risk of infection to their contacts.Antibody tests in theory can reveal who has been infected.

However, such tests may not provide 100% reliable results, including the fact that their sensitivity will vary buy kamagra oral jelly usa according to how common the infection is. If an infection is common, then a very sensitive test will identify all those infected and also a small number of false positives, but when the infection becomes less common, then the proportion of false positives will rise and a positive test could become less useful. Moreover, for how long would the antibody-person be immune?. Counting the number of buy kamagra oral jelly usa hospital deaths attributed to COVID-19 may be a guide to an epidemic, but deaths may be difficult to count in the community. In any case, changes in death numbers usually lag a few weeks behind the time of infection.Would a lower infecting dose cause the following illness to be less severe?.

Does the virus need several extra doubling times to exert its effects such that in this gained time host responses will be in a better position to combat the infection in high-risk groups or buy kamagra oral jelly usa in groups where medical care is minimal?. Could low-dose vaccination with COVID-19 itself be useful?. Shakespeare’s Hamlet (not an epidemiologist) suggested, ‘Diseases desperate grown, By desperate appliance are relieved, Or not at all’.All the aforementioned are key questions, the answers to many of which are not known at the time of writing and, even if they were, the answers might change with the passage of time.Various countries have made various policy choicesAt the time of writing (April 2020), COVID-19 has probably been in the human population for only about 6 months. In most countries, there are concerns about how the epidemic buy kamagra oral jelly usa was initially handled, and it is possible to predict some damming retrospective judgements. However, we should concentrate on where we are, not where we might have been.

Recriminations should wait.Many important decisions have to be made based on incomplete information. Most COVID-19 decisions have to be made on speculations (guesswork and wishful thinking), on hypotheses (propositions made as a basis for reasoning, without an assumption buy kamagra oral jelly usa of its truth) or on theories (suppositions or systems of ideas explaining something based on general principles). All COVID-19 decisions have to be made at the time ‘We have to start from where we are’ guided by the experiences of other countries that are ahead of us in the epidemic.Pandemics usually reveal inequalities and the poor, or those in unstable employment or in crowded accommodation, or with underlying health issues, or where healthcare is less affordable, or are in the less well educated will suffer the most. They will also comply less with restrictions. Ideologies, power blocks, leaders, social cohesion beliefs, the relevance of centralised or regional decision making, the abilities of popularism (political doctrines buy kamagra oral jelly usa chosen to appeal to a majority of the electorate), welfare states (usually capitalist nations that recognise that food, shelter, education and medicine are basic rights to be ensured by government actions) and authoritarianism are all being stress tested by COVID-19.

In the future, it will be interesting to judge how these societal systems played out when confronting the conflicting requirement to reconcile conflicting priorities of health and economic factors that involve conflicts between responding and planning for deaths (‘How should we cope with these’) and actually planning deaths. €˜We will have to accept that we will cause deaths whatever policy we adopt’.There is only one initial response to COVID-19 that reduces infection rates buy kamagra oral jelly usa and death rates. Dramatic quarantine ‘total lockdown’ measures. Some countries, including China, South Korea, Hong Kong, Taiwan and Singapore, hit the epidemic hard and early with lockdown quarantine to reduce the epidemic. Such countries perhaps tend towards acceptance of authoritarianism and their citizens less buy kamagra oral jelly usa rebellious than in other countries.

New Zealand did similarly. I could not possibly comment on the US responses. However, on what criteria and at what speed buy kamagra oral jelly usa should liberalisation of quarantine measure occur to avoid re-emergences?. There are in theory three final paths out of the COVID-19 crisis:First, a vaccine. Even a perfect vaccine would be buy kamagra oral jelly usa difficult to evaluate with changing risks in the community.

How protective would a vaccine be and for how long would it be effective?. Second, the identification of a treatment, either preventative or curative, so that the disease becomes a considerably less worrisome prospect even for those with comorbidities.Third, herd immunity, when enough of the population has acquired and survived COVID-19 and thus developed immunity with the infection persisting at a low level. Currently the only, not entirely definitive, way of estimating this is by measuring buy kamagra oral jelly usa antibodies such that there would not be enough opportunities for disease transmission for the virus to continue circulating through populations with an Ro of less than 1, but the risk would not disappear entirely. Moreover, how should immunity be monitored if antibody testing may not reflect herd immunity?. Allowing herd immunity to develop initially would result in a huge spike in hospitalisations and deaths that could overwhelm most healthcare services, and that is why flattening such spikes by quarantine was indicated.

With flattening, there would still be illness and deaths but at a controlled slower rate buy kamagra oral jelly usa and hopefully also smaller numbers, such that healthcare services could cope.There is a lot of opinion and numerous contributions by official and unofficial organisations and individuals who think their “single issue advice” should be followed. No one individual has the expertise required for management of all the complexities. Committees are required, including microbiologists, infectious diseases doctors, public health doctors, epidemiologists, hospital and general practice representatives, epidemic mathematical modellers and economic advisers. Politicians have the responsibility to buy kamagra oral jelly usa deliver decisions when, especially when, information is imperfect. How many people would be infected if we did nothing?.

What would the epidemic curve look like in various buy kamagra oral jelly usa situations?. What proportion of those infected would infect others in various situations?. How many of which population groups would require what extra healthcare services in various situations?. What would be the effect of various measures at various buy kamagra oral jelly usa times?. What economic impacts might there be when these in themselves affect mortality rates?.

I predict that COVID-19 will cause two significant changes in political thought. First, it has to buy kamagra oral jelly usa be realised that globalisation of such epidemics, and there will be more to come, will demand an integrated globalised response. Second, in 1987, Margaret Thatcher, the UK Prime Minister, said that ‘There is no such thing as society… the quality of our lives will depend on how much each of us is prepared to take responsibility for ourselves and each of us prepared to turn round and help by our own efforts those who are unfortunate’. The current UK Prime Minister in March 2020 presented a new synthesis, ‘There really is such a thing as society’.Finally, it is important to realise that everyone, no matter where they are, for better or worse, has to rely on their existing rulers or governments..

In 2003, severe acute respiratory syndrome (SARS) spread through 26 countries, infecting at least 8098 and causing at least 774 deaths (a case buy kamagra oral jelly nz fatality rate of official source 9.6%). Middle East respiratory syndrome (MERS) by January 2020 caused 2519 cases and 866 deaths (a case fatality rate of 34%). SARS and buy kamagra oral jelly nz MERS are coronaviruses and both are not as easily transmitted as COVID-19 because they require close contact with those infected (or also with camels in the case of MERS), and infected humans tend not to transmit before they have symptoms. Transmission of both mostly occurred within healthcare settings and could be controlled by improving infection control in hospitals.In 2015, Bill Gates in a TED lecture warned that we were more at risk of a global pandemic (he thought it would be influenza) than we were from nuclear war.COVID-19 probably first entered the human population in China in November 2019 in Wuhan and was first identified as such in December 2019. It spreads easily with a R0 (basic reproduction number) that represents the average number of people the average infected person would infect being between 1.5 and 3.5, depending on the surrounding circumstances.

While a large proportion of infections are asymptomatic, there is a significant mortality rate buy kamagra oral jelly nz (about 3.4% worldwide). Survival rates are worse in the elderly, in men and in those with comorbidities. There are no suitable mammal models to study.Because there is a significant proportion of asymptomatic infectious people, monitoring of epidemics necessitates screening to determine (1) the proportion of the population that is actively infected and or (2) the total number of those who have been infected. Both require buy kamagra oral jelly nz screening. To gain significant data, then whole populations or representative samples have to be tested.

In many circumstances, only those with high probability are tested.DNA polymerase techniques on throat swabs (notably real-time reverse transcription PCR) can identify the actively infected, but such tests will need to be repeated, especially in healthcare staff who buy kamagra oral jelly nz are both at increased risk of infection and could provide an increased risk of infection to their contacts.Antibody tests in theory can reveal who has been infected. However, such tests may not provide 100% reliable results, including the fact that their sensitivity will vary according to how common the infection is. If an infection is common, then a very sensitive test will identify all those infected and also a small number of false positives, but when the infection becomes less common, then the proportion of false positives will rise and a positive test could become less useful. Moreover, for how long would the antibody-person be immune? buy kamagra oral jelly nz. Counting the number of hospital deaths attributed to COVID-19 may be a guide to an epidemic, but deaths may be difficult to count in the community.

In any case, changes in death numbers usually lag a few weeks behind the time of infection.Would a lower infecting dose cause the following illness to be less severe?. Does the buy kamagra oral jelly nz virus need several extra doubling times to exert its effects such that in this gained time host responses will be in a better position to combat the infection in high-risk groups or in groups where medical care is minimal?. Could low-dose vaccination with COVID-19 itself be useful?. Shakespeare’s Hamlet (not an epidemiologist) suggested, ‘Diseases desperate grown, By desperate appliance are relieved, Or not at all’.All the aforementioned are key questions, the answers to many of which are not known at the time of writing and, even if they were, the answers might change with the passage of time.Various countries have made various policy choicesAt the time of writing (April 2020), COVID-19 has probably been in the human population for only about 6 months. In most countries, there are concerns about how the epidemic was initially handled, and it is possible to buy kamagra oral jelly nz predict some damming retrospective judgements.

However, we should concentrate on where we are, not where we might have been. Recriminations should wait.Many important decisions have to be made based on buy kamagra oral jelly nz incomplete information. Most COVID-19 decisions have to be made on speculations (guesswork and wishful thinking), on hypotheses (propositions made as a basis for reasoning, without an assumption of its truth) or on theories (suppositions or systems of ideas explaining something based on general principles). All COVID-19 decisions have to be made at the time ‘We have to start from where we are’ guided by the experiences of other countries that are ahead of us in the epidemic.Pandemics usually reveal inequalities and the poor, or those in unstable employment or in crowded accommodation, or with underlying health issues, or where healthcare is less affordable, or are in the less well educated will suffer the most. They will also comply less with restrictions buy kamagra oral jelly nz.

Ideologies, power blocks, leaders, social cohesion beliefs, the relevance of centralised or regional decision making, the abilities of popularism (political doctrines chosen to appeal to a majority of the electorate), welfare states (usually capitalist nations that recognise that food, shelter, education and medicine are basic rights to be ensured by government actions) and authoritarianism are all being stress tested by COVID-19. In the future, it will be interesting to judge how these societal systems played out when confronting the conflicting requirement to reconcile conflicting priorities of health and economic factors that involve conflicts between responding and planning for deaths (‘How should we cope with these’) and actually planning deaths. €˜We will have to accept that we will cause buy kamagra oral jelly nz deaths whatever policy we adopt’.There is only one initial response to COVID-19 that reduces infection rates and death rates. Dramatic quarantine ‘total lockdown’ measures. Some countries, including buy kamagra oral jelly nz China, South Korea, Hong Kong, Taiwan and Singapore, hit the epidemic hard and early with lockdown quarantine to reduce the epidemic.

Such countries perhaps tend towards acceptance of authoritarianism and their citizens less rebellious than in other countries. New Zealand did similarly. I could not buy kamagra oral jelly nz possibly comment on the US responses. However, on what criteria and at what speed should liberalisation of quarantine measure occur to avoid re-emergences?. There are in theory three final paths out of the COVID-19 crisis:First, a vaccine.

Even a perfect vaccine buy kamagra oral jelly nz would be difficult to evaluate with changing risks in the community. How protective would a vaccine be and for how long would it be effective?. Second, the identification of a treatment, either preventative or curative, so that the disease becomes a considerably less worrisome prospect even for those with comorbidities.Third, herd immunity, when enough of the population has acquired and survived COVID-19 and thus developed immunity with the infection persisting at a low level. Currently the only, not entirely definitive, way of estimating this is by measuring buy kamagra oral jelly nz antibodies such that there would not be enough opportunities for disease transmission for the virus to continue circulating through populations with an Ro of less than 1, but the risk would not disappear entirely. Moreover, how should immunity be monitored if antibody testing may not reflect herd immunity?.

Allowing herd immunity to develop initially would result in a huge spike buy kamagra oral jelly nz in hospitalisations and deaths that could overwhelm most healthcare services, and that is why flattening such spikes by quarantine was indicated. With flattening, there would still be illness and deaths but at a controlled slower rate and hopefully also smaller numbers, such that healthcare services could cope.There is a lot of opinion and numerous contributions by official and unofficial organisations and individuals who think their “single issue advice” should be followed. No one individual has the expertise required for management of all the complexities. Committees are required, including microbiologists, infectious diseases doctors, public health buy kamagra oral jelly nz doctors, epidemiologists, hospital and general practice representatives, epidemic mathematical modellers and economic advisers. Politicians have the responsibility to deliver decisions when, especially when, information is imperfect.

How many people would be infected if we did nothing?. What would buy kamagra oral jelly nz the epidemic curve look like in various situations?. What proportion of those infected would infect others in various situations?. How many of which population groups would require what extra healthcare services in various situations?. What would be the effect of various measures at various times? buy kamagra oral jelly nz.

What economic impacts might there be when these in themselves affect mortality rates?. I predict that COVID-19 will cause two significant changes in buy kamagra oral jelly nz political thought. First, it has to be realised that globalisation of such epidemics, and there will be more to come, will demand an integrated globalised response. Second, in 1987, Margaret Thatcher, the UK Prime Minister, said that ‘There is no such thing as society… the quality of our lives will depend on how much each of us is prepared to take responsibility for ourselves and each of us prepared to turn round and help by our own efforts those who are unfortunate’. The current UK Prime Minister in March 2020 presented a new synthesis, kamagra oral jelly in chennai ‘There really is such a thing as society’.Finally, it is important to realise that everyone, no matter where they are, for better or worse, has buy kamagra oral jelly nz to rely on their existing rulers or governments.In 2003, severe acute respiratory syndrome (SARS) spread through 26 countries, infecting at least 8098 and causing at least 774 deaths (a case fatality rate of 9.6%).

Middle East respiratory syndrome (MERS) by January 2020 caused 2519 cases and 866 deaths (a case fatality rate of 34%). SARS and MERS are coronaviruses and both are not as easily transmitted as COVID-19 because they require close contact with those infected (or also with camels in the case of MERS), and infected humans tend not to transmit before they have symptoms. Transmission of both mostly occurred within healthcare settings and could be controlled by improving infection control in hospitals.In 2015, Bill Gates in a TED lecture warned that we were more at risk of a global pandemic (he thought it would be influenza) than we were from nuclear war.COVID-19 probably first entered the human population in buy kamagra oral jelly nz China in November 2019 in Wuhan and was first identified as such in December 2019. It spreads easily with a R0 (basic reproduction number) that represents the average number of people the average infected person would infect being between 1.5 and 3.5, depending on the surrounding circumstances. While a large proportion of infections are asymptomatic, there buy kamagra oral jelly nz is a significant mortality rate (about 3.4% worldwide).

Survival rates are worse in the elderly, in men and in those with comorbidities. There are no suitable mammal models to study.Because there is a significant proportion of asymptomatic infectious people, monitoring of epidemics necessitates screening to determine (1) the proportion of the population that is actively infected and or (2) the total number of those who have been infected. Both require buy kamagra oral jelly nz screening. To gain significant data, then whole populations or representative samples have to be tested. In many circumstances, only those with high probability are tested.DNA polymerase techniques on throat swabs (notably real-time reverse transcription PCR) can identify the actively infected, but such tests will need to be repeated, especially in healthcare staff who are both at increased risk of infection and could provide an increased risk of infection to their contacts.Antibody tests in theory can reveal who has been infected.

However, such tests may not provide 100% reliable results, including the fact that their sensitivity will vary according to how buy kamagra oral jelly nz common the infection is. If an infection is common, then a very sensitive test will identify all those infected and also a small number of false positives, but when the infection becomes less common, then the proportion of false positives will rise and a positive test could become less useful. Moreover, for how long would the antibody-person be immune?. Counting the number of hospital deaths attributed to COVID-19 may be a guide to an epidemic, but deaths may be difficult buy kamagra oral jelly nz to count in the community. In any case, changes in death numbers usually lag a few weeks behind the time of infection.Would a lower infecting dose cause the following illness to be less severe?.

Does the virus need several extra doubling times to exert its effects such that in this gained time host responses will be in a better position to combat the infection in high-risk groups buy kamagra oral jelly nz or in groups where medical care is minimal?. Could low-dose vaccination with COVID-19 itself be useful?. Shakespeare’s Hamlet (not an epidemiologist) suggested, ‘Diseases desperate grown, By desperate appliance are relieved, Or not at all’.All the aforementioned are key questions, the answers to many of which are not known at the time of writing and, even if they were, the answers might change with the passage of time.Various countries have made various policy choicesAt the time of writing (April 2020), COVID-19 has probably been in the human population for only about 6 months. In most countries, there are concerns about how the epidemic was initially handled, and buy kamagra oral jelly nz it is possible to predict some damming retrospective judgements. However, we should concentrate on where we are, not where we might have been.

Recriminations should wait.Many important decisions have to be made based on incomplete information. Most COVID-19 decisions have to be made on speculations (guesswork and wishful thinking), on buy kamagra oral jelly nz hypotheses (propositions made as a basis for reasoning, without an assumption of its truth) or on theories (suppositions or systems of ideas explaining something based on general principles). All COVID-19 decisions have to be made at the time ‘We have to start from where we are’ guided by the experiences of other countries that are ahead of us in the epidemic.Pandemics usually reveal inequalities and the poor, or those in unstable employment or in crowded accommodation, or with underlying health issues, or where healthcare is less affordable, or are in the less well educated will suffer the most. They will also comply less with restrictions. Ideologies, power blocks, leaders, social cohesion beliefs, the relevance of centralised or regional decision making, the abilities of popularism (political doctrines chosen to appeal to a majority of the electorate), welfare states (usually capitalist nations that recognise that food, shelter, education and medicine are basic rights to be ensured by government actions) and authoritarianism are all being stress buy kamagra oral jelly nz tested by COVID-19.

In the future, it will be interesting to judge how these societal systems played out when confronting the conflicting requirement to reconcile conflicting priorities of health and economic factors that involve conflicts between responding and planning for deaths (‘How should we cope with these’) and actually planning deaths. €˜We will have to accept that we will cause deaths whatever policy we adopt’.There is only one initial response to COVID-19 that reduces buy kamagra oral jelly nz infection rates and death rates. Dramatic quarantine ‘total lockdown’ measures. Some countries, including China, South Korea, Hong Kong, Taiwan and Singapore, hit the epidemic hard and early with lockdown quarantine to reduce the epidemic. Such countries perhaps tend towards acceptance of authoritarianism and their citizens less rebellious than in other buy kamagra oral jelly nz countries.

New Zealand did similarly. I could not possibly comment on the US responses. However, on what criteria and at what speed should liberalisation of quarantine measure occur to buy kamagra oral jelly nz avoid re-emergences?. There are in theory three final paths out of the COVID-19 crisis:First, a vaccine. Even a perfect buy kamagra oral jelly nz vaccine would be difficult to evaluate with changing risks in the community.

How protective would a vaccine be and for how long would it be effective?. Second, the identification of a treatment, either preventative or curative, so that the disease becomes a considerably less worrisome prospect even for those with comorbidities.Third, herd immunity, when enough of the population has acquired and survived COVID-19 and thus developed immunity with the infection persisting at a low level. Currently the only, not entirely definitive, way of estimating this is by measuring antibodies such that there would not be enough opportunities for disease transmission for the virus to continue circulating through populations with an Ro buy kamagra oral jelly nz of less than 1, but the risk would not disappear entirely. Moreover, how should immunity be monitored if antibody testing may not reflect herd immunity?. Allowing herd immunity to develop initially would result in a huge spike in hospitalisations and deaths that could overwhelm most healthcare services, and that is why flattening such spikes by quarantine was indicated.

With flattening, there would still be illness and deaths but at a controlled slower rate and hopefully also smaller numbers, such that healthcare services could cope.There is a lot of opinion and numerous contributions by official and unofficial organisations and individuals who think their “single issue advice” buy kamagra oral jelly nz should be followed. No one individual has the expertise required for management of all the complexities. Committees are required, including microbiologists, infectious diseases doctors, public health doctors, epidemiologists, hospital and general practice representatives, epidemic mathematical modellers and economic advisers. Politicians have the responsibility to deliver decisions when, especially when, information is imperfect buy kamagra oral jelly nz. How many people would be infected if we did nothing?.

What would the epidemic curve look like in various buy kamagra oral jelly nz situations?. What proportion of those infected would infect others in various situations?. How many of which population groups would require what extra healthcare services in various situations?. What would be buy kamagra oral jelly nz the effect of various measures at various times?. What economic impacts might there be when these in themselves affect mortality rates?.

I predict that COVID-19 will cause two significant changes in political thought. First, it has to be realised that globalisation of such epidemics, and there will be more to come, will buy kamagra oral jelly nz demand an integrated globalised response. Second, in 1987, Margaret Thatcher, the UK Prime Minister, said that ‘There is no such thing as society… the quality of our lives will depend on how much each of us is prepared to take responsibility for ourselves and each of us prepared to turn round and help by our own efforts those who are unfortunate’. The current UK Prime Minister in March 2020 presented a new synthesis, ‘There really is such a thing as society’.Finally, it is important to realise that everyone, no matter where they are, for better or worse, has to rely on their existing rulers or governments..

Super kamagra uk

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Elon Musk on Friday unveiled a coin-sized prototype of a brain implant developed by his startup Neuralink to enable people who are paralyzed to operate smartphones and robotic limbs with their thoughts — and said the company had worked to “dramatically simplify” the device since presenting an earlier version last summer.In an event live-streamed look at this site on YouTube to more than 150,000 viewers at one point, the company staged a demonstration in which it trotted out super kamagra uk a pig named Gertrude that was said to have had the company’s device implanted in its head two months ago. The live stream showed what Musk claimed to be Gertrude’s real-time brain activity as it sniffed around a pen. At no point, though, did he provide evidence that the signals — rendered in beeps and bright blue wave patterns on screen — were, in fact, emanating from the pig’s brain.A pig presented at a Neuralink demonstration was said to have one of the super kamagra uk company’s brain implants in its head. YouTube screenshot“This is obviously sounding increasingly like a Black Mirror episode,” Musk said at one point during the event as he responded affirmatively to a question about whether the company’s implant could eventually be used to save and replay memories.

€œThe future’s going to be weird.”advertisement Musk said that in July Neuralink received a breakthrough device designation from the Food and Drug Administration — a regulatory pathway that could allow the company to soon start super kamagra uk a clinical trial in people with paraplegia and tetraplegia. The big reveal came after four former Neuralink employees told STAT that the company’s leaders have long fostered an internal culture characterized by rushed timelines and the “move fast and break things” ethos of a tech company — a pace sometimes at odds with the slow and incremental pace that’s typical of medical device development. Advertisement Friday’s event began, 40 minutes late, with a glossy video about the company’s work — and then panned to Musk, standing in front of a blue curtain beside a gleaming new version of the company’s surgical “sewing machine” robot that could easily super kamagra uk have been mistaken for a giant Apple device. Musk described the event as a “product demo” and said its primary purpose was to recruit potential new employees.

It was unclear whether the demonstration was taking place at the company’s Fremont, super kamagra uk Calif., headquarters or elsewhere. Musk proceeded to reveal the new version of Neuralink’s brain implant, which he said was designed to fit snugly into the top of the skull. Neuralink’s technological design has super kamagra uk changed significantly since its last big update in July 2019. At that time, the company’s brain implant system involved a credit-card sized device designed to be positioned behind the back of a person’s ear, with several wires stretching to the top of the skull.

After demonstrating the pig’s brain activity at Friday’s event, Musk showed video footage of a pig walking on a treadmill and said Neuralink’s device could be used super kamagra uk to “predict the position of limbs with high accuracy.” That capability would be critical to allowing someone using the device to do something like controlling a prosthetic limb, for example.Neuralink for months has signaled that it initially plans to develop its device for people who are paralyzed. It said at its July 2019 event that it wanted to start human testing by the end of 2020. Receiving the breakthrough device designation from the FDA — designed to speed up the lengthy regulatory process — is a step forward, but it by no super kamagra uk means guarantees that a device will receive a green light, either in a short or longer-term time frame. After Musk’s presentation, a handful of the company’s employees — all wearing masks, but seated only inches apart — joined him to take questions submitted on Twitter or from the small audience in the room.In typical fashion for a man who in 2018 sent a Tesla Roadster into space, Musk didn’t hesitate to use the event to cross-promote his electric car company.

Asked whether the Neuralink chip would allow people super kamagra uk to summon their Tesla telepathically, Musk responded. €œDefinitely — of course.”Matthew MacDougall, the company’s head neurosurgeon, appearing in scrubs, said the company had so far only implanted its technology into the brain’s cortical surface, the coaster-width layer enveloping the brain, but added that it hoped to go deeper in the future. Still, Musk super kamagra uk said. €œYou could solve blindness, you could solve paralysis, you could solve hearing — you can solve a lot just by interfacing with the cortex.”Musk and MacDougall said they hoped to eventually implant Neuralink’s devices — which they referred to on stage simply as “links” — in the deeper structures of the brain, such as in the hypothalamus, which is believed to play a critical role in mental illnesses including depression, anxiety, and PTSD.There were no updates at the event of Neuralink’s research in monkeys, which the company has been conducting in partnership with the University of California, Davis since 2017.

At last July’s event, Musk said — without providing evidence — that a monkey had controlled a computer with its brain.At that same July 2019 event, Neuralink released a preprint paper — published a few months later — that claimed to show that a series of Neuralink electrodes implanted in the brains of super kamagra uk rats could record neural signals. Critically, the work did not show where in the brain the implanted electrodes were recording from, for how long they were recording, or whether the recordings could be linked to any of the rats’ bodily movements.In touting Friday’s event — and Neuralink’s technological capabilities — on Twitter in recent weeks, Musk spoke of “AI symbiosis while u wait” and referenced the “matrix in the matrix” — a science-fiction reference about revealing the true nature of reality. The progress super kamagra uk the company reported on Friday fell far short of that. Neuralink’s prototype is ambitious, but it has yet to show evidence that it can match up to the brain-machine interfaces developed by academic labs and other companies.

Other groups have shown that they can listen in on neural activity and allow primates and people to control a computer cursor with their brain — so-called “read-out” technology — and super kamagra uk have also shown that they can use electrical stimulation to input information, such as a command or the heat of a hot cup of coffee, using “write-in” technology. Neuralink said on Friday that its technology would have both read-out and write-in capabilities.Musk acknowledged that Neuralink still has a long way to go. In closing the event after more than 70 minutes, Musk said super kamagra uk. €œThere’s a tremendous amount of work to be done to go from here to a device that is widely available and affordable and reliable.”Following the news this week of what appears to have been the first confirmed case of a Covid-19 reinfection, other researchers have been coming forward with their own reports.

One in Belgium, another in the super kamagra uk Netherlands. And now, one in Nevada.What caught experts’ attention about the case of the 25-year-old Reno man was not that he appears to have contracted SARS-CoV-2 (the name of the virus that causes Covid-19) a second time. Rather, it’s super kamagra uk that his second bout was more serious than his first.Immunologists had expected that if the immune response generated after an initial infection could not prevent a second case, then it should at least stave off more severe illness. That’s what occurred with the first known reinfection case, in a 33-year-old Hong Kong man.advertisement Still, despite what happened to the man in Nevada, researchers are stressing this is not a sky-is-falling situation or one that should result in firm conclusions.

They always presumed people would become vulnerable to Covid-19 again some time super kamagra uk after recovering from an initial case, based on how our immune systems respond to other respiratory viruses, including other coronaviruses. It’s possible that these early cases of reinfection are outliers and have features that won’t apply to the tens of millions of other people who have already shaken off Covid-19.“There are millions and millions of cases,” said Michael Mina, an epidemiologist at Harvard’s T.H. Chan School of super kamagra uk Public Health. The real question that should get the most focus, Mina said, is, “What happens to most people?.

€advertisement But with more reinfection reports likely to make it into the scientific literature soon, and from super kamagra uk there into the mainstream press, here are some things to look for in assessing them.What’s the deal with the Nevada case?. The Reno resident in question first tested positive for SARS-CoV-2 in April after coming down with a sore throat, cough, and headache, as well as nausea and diarrhea. He got better super kamagra uk over time and later tested negative twice. But then, some 48 days later, the man started experiencing headaches, cough, and other symptoms again.

Eventually, he became so sick that he had to be hospitalized and was found to have pneumonia.Researchers sequenced virus samples from both of his infections and found they were different, providing evidence that this was a new infection distinct from the first. What super kamagra uk happens when we get Covid-19 in the first case?. Researchers are finding that, generally, people who get Covid-19 develop a healthy immune response replete with both antibodies (molecules that can block pathogens from infecting cells) and T cells (which help wipe out the virus). This is what happens after other viral infections.In addition to fending off the virus the first time, that immune response also creates memories super kamagra uk of the virus, should it try to invade a second time.

It’s thought, then, that people who recover from Covid-19 will typically be protected from another case for some amount of time. With other coronaviruses, super kamagra uk protection is thought to last for perhaps a little less than a year to about three years.But researchers can’t tell how long immunity will last with a new pathogen (like SARS-CoV-2) until people start getting reinfected. They also don’t know exactly what mechanisms provide protection against Covid-19, nor do they know what levels of antibodies or T cells are required to signal that someone is protected through a blood test. (These are called the “correlates of protection.”) Why do experts expect second super kamagra uk cases to be milder?.

With other viruses, protective immunity doesn’t just vanish one day. Instead, it super kamagra uk wanes over time. Researchers have then hypothesized that with SARS-CoV-2, perhaps our immune systems might not always be able to prevent it from getting a toehold in our cells — to halt infection entirely — but that it could still put up enough of a fight to guard us from getting really sick. Again, this is what happens with other respiratory super kamagra uk pathogens.And it’s why some researchers actually looked at the Hong Kong case with relief.

The man had mild to moderate Covid-19 symptoms during the first case, but was asymptomatic the second time. It was a demonstration, experts said, of what you would want super kamagra uk your immune system to do. (The case was only detected because the man’s sample was taken at the airport when he arrived back in Hong Kong after traveling in Europe.)“The fact that somebody may get reinfected is not surprising,” Malik Peiris, a virologist at the University of Hong Kong, told STAT earlier this week about the first reinfection. €œBut the super kamagra uk reinfection didn’t cause disease, so that’s the first point.”The Nevada case, then, provides a counterexample to that.

What kind of immune response did the person who was reinfected generate initially?. Earlier, we described the robust immune response super kamagra uk that most people who have Covid-19 seem to mount. But that was a generalization. Infections and the immune responses they induce in different people are “heterogeneous,” said Sarah Cobey, an epidemiologist and evolutionary biologist at the University of Chicago.Older people often generate super kamagra uk weaker immune responses than younger people.

Some studies have also indicated that milder cases of Covid-19 induce tamer immune responses that might not provide as lasting or as thorough of a defense as stronger immune responses. The man in Hong Kong, for example, did not generate antibodies to the virus after his first super kamagra uk infection, at least to the level that could be detected by blood tests. Perhaps that explains why he contracted the virus again just about 4 1/2 months after recovering from his initial infection.In the Nevada case, researchers did not test what kind of immune response the man generated after the first case.“Infection is not some binary event,” Cobey said. And with reinfection, “there’s going to be some viral replication, but the question is how much is the immune system getting super kamagra uk engaged?.

€What might be broadly meaningful is when people who mounted robust immune responses start getting reinfected, and how severe their second cases are. Are people who have Covid-19 a second super kamagra uk time infectious?. As discussed, immune memory can prevent reinfection. If it can’t, it might stave off serious super kamagra uk illness.

But there’s a third aspect of this, too.“The most important question for reinfection, with the most serious implications for controlling the pandemic, is whether reinfected people can transmit the virus to others,” Columbia University virologist Angela Rasmussen wrote in Slate this week.Unfortunately, neither the Hong Kong nor the Reno studies looked at this question. But if most people who super kamagra uk get reinfected don’t spread the virus, that’s obviously good news. What happens when people broadly become susceptible again?. Whether it’s six months after the first infection or nine months or a year or super kamagra uk longer, at some point, protection for most people who recover from Covid-19 is expected to wane.

And without the arrival of a vaccine and broad uptake of it, that could change the dynamics of local outbreaks.In some communities, it’s thought that more than 20% of residents have experienced an initial Covid-19 case, and are thus theoretically protected from another case for some time. That is still below the point of herd immunity — when enough people are immune that transmission doesn’t occur — but still, the fewer vulnerable people there are, the less likely spread is to occur.On the flip side though, if more people become susceptible to the super kamagra uk virus again, that could increase the risk of transmission. Modelers are starting to factor that possibility into their forecasts.A crucial question for which there is not an answer yet is whether what happened to the man in Reno, where the second case was more severe than the first, remains a rare occurrence, as researchers expect and hope. As the Nevada researchers wrote, “the generalizability of this finding is unknown.”An advocacy group has asked the Department of Defense to investigate what it called “an apparent failure” by Moderna (MRNA) to disclose millions of dollars in awards received from the Defense Advanced Research Projects Agency in patent applications the company filed for vaccines.In a letter to super kamagra uk the agency, Knowledge Ecology International explained that a review of dozens of patent applications found the company received approximately $20 million from the federal government in grants several years ago and the funds “likely” led to the creation of its vaccine technology.

This was used to develop vaccines to combat different viruses, such as Zika and, later, the virus that causes Covid-19.In arguing for an investigation, the advocacy group maintained Moderna is obligated under federal law to disclose the grants that led to nearly a dozen specific patent applications and explained the financial support means the U.S. Government would super kamagra uk have certain rights over the patents. In other words, U.S. Taxpayers would have an ownership stake in vaccines super kamagra uk developed by the company.advertisement “This clarifies the public’s right in the inventions,” said Jamie Love, who heads Knowledge Ecology International, a nonprofit that tracks patents and access to medicines issues.

€œThe disclosure (also) changes the narrative about who has financed the inventive activity, often the most risky part of development.” advertisement One particular patent assigned to Moderna concerns methods and compositions that can be used specifically against coronaviruses, including COVID-19. The patent names a Moderna scientist and a former Moderna scientist as inventors, both of which acknowledged performing work under the DARPA awards in two academic papers, according to the report by the advocacy group.The group examined the 126 patents assigned to Moderna or ModernaTx as well as 154 patent applications. €œDespite the super kamagra uk evidence that multiple inventions were conceived in the course of research supported by the DARPA awards, not a single one of the patents or applications assigned to Moderna disclose U.S. Federal government funding,” the report stated.We asked Moderna and the Department of Defense for comment and will update you accordingly.The missive to the Department of Defense follows a recent analysis by Public Citizen, another advocacy group, indicating the National Institutes of Health may own mRNA-1273, the Moderna vaccine candidate for Covid-19.

The advocacy group noted the federal government filed multiple patents covering the vaccine and two patent applications, super kamagra uk in particular, list federal scientists as co-inventors.The analyses are part of a larger campaign among advocacy groups and others in the U.S. And elsewhere to ensure that Covid-19 medical products are available to poor populations around the world. The concern reflects the unprecedented global demand super kamagra uk for therapies and vaccines, and a race among wealthy nations to snap up supplies from vaccine makers. In the U.S., the effort has focused on the extent to which the federal government has provided taxpayer dollars to different companies to help fund their discoveries.

In some cases, advocates argue that federal funding super kamagra uk matters because it clarifies the rights that the U.S. Government has to ensure a therapy or vaccine is available to Americans on reasonable terms.One example has been remdesivir, the Gilead Sciences (GILD) treatment being given to hospitalized Covid-19 patients. The role played by super kamagra uk the U.S. Government in developing remdesivir to combat coronaviruses involved contributions from government personnel at such agencies as the U.S.

Army Medical Research Institute of Infectious Diseases.As for the Moderna vaccine, earlier this month, the company was awarded a $1.525 billion contract by the Department of Defense and super kamagra uk the Department of Health and Human Services to manufacture and deliver 100 million doses of its Covid-19 vaccine. The agreement also includes an option to purchase another 400 million doses, although the terms were not disclosed. In announcing the super kamagra uk agreement, the government said it would ensure Americans receive the Covid-19 vaccine at no cost, although they may be charged by health care providers for administering a shot.In this instance, however, Love said the “letter is not about price or profits. It’s about (Moderna) not owning up to DARPA funding inventions.

If the U.S super kamagra uk. Wants to pay for all of the development of Moderna’s vaccine, as Moderna now acknowledges, and throw in a few more billion now, and an option to spend billions more, it’s not unreasonable to have some transparency over who paid for their inventions.”This is not the first time Moderna has been accused of insufficient disclosure. Earlier this month, Knowledge Ecology International and Public super kamagra uk Citizen maintained the company failed to disclose development costs in a $955 million contract awarded by BARDA for its Covid-19 vaccine. In all, the federal government has awarded the company approximately $2.5 billion to develop the vaccine.The coming few weeks represent a crucial moment for an ambitious plan to try to secure Covid-19 vaccines for roughly 170 countries around the world without the deep pockets to compete for what will be scarce initial supplies.Under the plan, countries that want to pool resources to buy vaccines must notify the World Health Organization and other organizers — Gavi, the Vaccine Alliance, as well as the Coalition for Epidemic Preparedness Innovations — of their intentions by Monday.

That means it’s fish-or-cut-bait time for the so-called COVAX facility.Already, wealthy countries — the United States, super kamagra uk the United Kingdom, Japan, Canada, and Australia, among others, as well as the European Union — have opted to buy their own vaccine, signing bilateral contracts with manufacturers that have secured billions of doses of vaccine already. That raises the possibility that less wealthy countries will be boxed out of supplies.advertisement And yet Richard Hatchett, the CEO of CEPI, insists there is a path to billions of doses of vaccine for the rest of the world in 2021. STAT spoke with Hatchett this week super kamagra uk. A transcript of the conversation, lightly edited for clarity and length, follows.

You said this super kamagra uk is a critical time for CEPI. Can you explain what needs to happen between now and mid-September for this joint purchasing approach to be a success?. Advertisement The super kamagra uk critical moment is now for countries to commit to the COVAX facility, because that will enable us to secure ample quantities of vaccine and then to be able to convey when that vaccine is likely to become available based on current information.What we’re now here asking countries to do is to indicate their intent to participate by Aug. 31, and to make a binding commitment by Sept.

18. And to provide funds in support of that binding commitment by early October. Our negotiations with companies are already taking place and it will be important for us from a planning purpose that countries indicate their intent to participate.Those binding commitments we think will be sufficient to allow us to then secure the advance purchase agreements, particularly with those companies that don’t have a prior contractual obligation to COVAX. And then obviously, we need the funds to live up to those advance purchase agreements.Is it possible this thing could still fall apart?.

There appears to be some concern COVAX has been boxed out by rich countries. There was always a possibility that there wouldn’t be sufficient uptake. But I think we’re very encouraged at this point by the level of commitment, both from countries that would be beneficiaries of the advance market commitment — that’s the lower-income, lower-middle-income countries — as well as the self-financing countries. To have over 170 countries expressing interest in participating — they see the value.We’re much more encouraged now that it’s not going to fall apart.

We still need to bring it off to maximize its value. And we’re right at the crunch moment where countries are going to have to make these commitments. So, the next month is really absolutely critical to the facility. I am confident at this point that the world recognizes the value and wants it to work.I’ve been keeping tabs on advance purchase agreements that have been announced.

And at this point, a small number of rich countries have nailed down a lot of vaccine — more than 3 billion doses. How hard does that make your job?. The fact that they’re doing it creates anxiety among other countries. And that in itself can accelerate the pace.

So, I’m not going to say that we’re not watching that with concern.I will say that for COVAX and the facility, this is absolutely critical moment. I think we still have a window of opportunity between now and mid-September — when we’re asking that the self-financing countries to make their commitments — to make the facility real and to make it work. Between doses that are committed to COVAX through the access agreements and other agreements — these are discussions with partners that CEPI has funded as well as partners that CEPI has not funded — we still see a pathway for COVAX to well over 3 billion doses in 2021.I think it’s really important to bear in mind is that there are at least a few countries — and I think the U.S. And the U.K.

Most publicly — that may be in a situation of significant oversupply. I believe the U.S. And U.K. Numbers, if you add them together, would result in enough vaccine for 600 million people to receive two doses of vaccine each.

And, you know, there is no possible way that the U.S. Or the U.K. Can use that much vaccine.So, there may be a lot of extra supply that looks like it’s been tied up sloshing around later. I don’t think that the bilateral deals that have been struck are going to prevent COVAX from achieving its goals.But if so much vaccine has been pre-ordered by rich countries, can countries in the COVAX pool get enough for their needs?.

One of the things that we’ve argued through COVAX is that to control the pandemic or to end the acute phase of the pandemic to allow normalcy to start to reassert itself, you don’t have to vaccinate 100% of your population.You need to vaccinate those at greatest risk for bad outcomes and you need to vaccinate certain critical workers, particularly your health care workforce. And if you can achieve that goal, which for most countries means vaccinating between 20% and maybe 30% of the population, then you can transform the pandemic into something that is much more manageable. Then you can buy yourself time to vaccinate everybody who wants to be vaccinated.We’ve argued the COVAX facility really offers the world the best shot at doing that globally in the fastest possible way, as well as providing for equitable access. This is a case where doing the equitable thing is also doing the efficient thing.CEPI has provided funding to nine vaccines.

Is it true that all those manufacturers aren’t required to provide the COVAX facility with vaccine?. That is correct. One of the things that we did, and I think it was an important role that CEPI played early on, was that we moved money very, very quickly, in small increments. You know, some of the early contracts were only $5 million or $10 million, to get programs up and running while we potentially put in place much larger-scale, longer-term contracts.If you were doing it over again, would you have given money without strings attached?.

Yes, I think I would have. I think that was critically important to initiating programs.Our contract with Moderna was established in about 48 hours. And that provided critical funding to them to manufacture doses that got them into clinical trials within nine weeks of the genetic sequences [of the SARS-CoV-2 virus] being released.And if you look at the nine programs that we’ve invested in, seven are in clinical trials. Two — the AstraZeneca program now and the Moderna program — are among the handful in Phase 3 clinical trials.

And, I think the number of projects that that we funded initially, which started in kind of a biotech or academic phase that have now been picked up by large multinational corporations, there’s at least four. The Themis program being picked up by Merck, Oxford University by AstraZeneca, the University of Queensland by CSL, and Clover being in partnership with GSK, I think that speaks to the quality of the programs that we selected.So, I think that combination of rapid review, speed of funding, getting those programs started, getting them oriented in the right direction, I think all of that is critical to where we are now.Companies that got money from CEPI to build out production capacity — that money came with strings attached, right?. Yes, exactly. So, where CEPI has made investments that create manufacturing, or secure manufacturing capacity, the commitment has been that the capacity that is attributable to the CEPI investment is committed — at least right of first refusal — to the global procurement facility.WASHINGTON — The Trump administration removed a top Food and Drug Administration communications official from her post on Friday in the wake of several controversial agency misstatements, a senior administration official confirmed to STAT.The spokeswoman, Emily Miller, had played a lead role in defending the FDA commissioner, Stephen Hahn, after he misrepresented data regarding the use of blood plasma from recovered Covid-19 patients.

The New York Times first reported Miller’s ouster. Miller’s tenure at as the top FDA spokeswoman lasted only 11 days. Her appointment was viewed with alarm by agency officials who felt her presence at the agency was emblematic of broader political pressure from the Trump administration, STAT first reported earlier this week.advertisement Before joining the FDA, Miller had no experience in health or medicine. Her former role as assistant commissioner for media affairs is typically not an appointment filled by political appointees.

The FDA’s communications arm typically maintains a neutral, nonpolitical tone.Miller’s appointment particularly alarmed FDA staff and outside scientists given her history in right-wing political advocacy and conservatism journalism. Her résumé included a stint as a Washington Times columnist, where she penned columns with titles that include “New Obamacare ads make young women look like sluts,” and a 2013 book on gun rights titled “Emily Gets Her Gun. But Obama Wants to Take Yours.”advertisement She also worked as a reporter for One America News Network, a right-wing cable channel that frequently espouses conspiracy theories and has declared an open alliance with President Trump.Miller quickly made her presence known at the FDA. In the wake of Hahn’s misstatements on blood plasma, she aggressively defended the commissioner, falsely claiming in a tweet that the therapy “has shown to be beneficial for 35% of patients.” An FDA press release on blood plasma, issued less than a week after her appointment, similarly alarmed agency insiders by trumpeting the emergency authorization as “Another Achievement in Administration’s Fight Against [the] Pandemic.”.

Elon Musk on Friday unveiled a coin-sized prototype of a brain buy kamagra oral jelly nz implant developed http://sw.keimfarben.de/buy-kamagra-online-without-prescription/ by his startup Neuralink to enable people who are paralyzed to operate smartphones and robotic limbs with their thoughts — and said the company had worked to “dramatically simplify” the device since presenting an earlier version last summer.In an event live-streamed on YouTube to more than 150,000 viewers at one point, the company staged a demonstration in which it trotted out a pig named Gertrude that was said to have had the company’s device implanted in its head two months ago. The live stream showed what Musk claimed to be Gertrude’s real-time brain activity as it sniffed around a pen. At no point, though, did he provide buy kamagra oral jelly nz evidence that the signals — rendered in beeps and bright blue wave patterns on screen — were, in fact, emanating from the pig’s brain.A pig presented at a Neuralink demonstration was said to have one of the company’s brain implants in its head. YouTube screenshot“This is obviously sounding increasingly like a Black Mirror episode,” Musk said at one point during the event as he responded affirmatively to a question about whether the company’s implant could eventually be used to save and replay memories. €œThe future’s going to be weird.”advertisement Musk said that in July Neuralink received a breakthrough device designation from the Food and Drug Administration — a regulatory pathway that could allow the company to soon start a buy kamagra oral jelly nz clinical trial in people with paraplegia and tetraplegia.

The big reveal came after four former Neuralink employees told STAT that the company’s leaders have long fostered an internal culture characterized by rushed timelines and the “move fast and break things” ethos of a tech company — a pace sometimes at odds with the slow and incremental pace that’s typical of medical device development. Advertisement Friday’s event began, 40 minutes late, with a glossy video about the company’s work — and then panned to Musk, standing in front of a blue curtain beside a gleaming new version of the company’s surgical “sewing machine” robot that buy kamagra oral jelly nz could easily have been mistaken for a giant Apple device. Musk described the event as a “product demo” and said its primary purpose was to recruit potential new employees. It was unclear whether the demonstration was taking place at the company’s Fremont, Calif., headquarters buy kamagra oral jelly nz or elsewhere. Musk proceeded to reveal the new version of Neuralink’s brain implant, which he said was designed to fit snugly into the top of the skull.

Neuralink’s technological buy kamagra oral jelly nz design has changed significantly since its last big update in July 2019. At that time, the company’s brain implant system involved a credit-card sized device designed to be positioned behind the back of a person’s ear, with several wires stretching to the top of the skull. After demonstrating the pig’s brain activity at Friday’s event, Musk showed video footage of a pig walking on a treadmill and said Neuralink’s device could be used to “predict the position of limbs with high accuracy.” That capability would be critical to allowing someone using the device to do something like controlling buy kamagra oral jelly nz a prosthetic limb, for example.Neuralink for months has signaled that it initially plans to develop its device for people who are paralyzed. It said at its July 2019 event that it wanted to start human testing by the end of 2020. Receiving the breakthrough device designation from the FDA — designed to speed up the lengthy regulatory buy kamagra oral jelly nz process — is a step forward, but it by no means guarantees that a device will receive a green light, either in a short or longer-term time frame.

After Musk’s presentation, a handful of the company’s employees — all wearing masks, but seated only inches apart — joined him to take questions submitted on Twitter or from the small audience in the room.In typical fashion for a man who in 2018 sent a Tesla Roadster into space, Musk didn’t hesitate to use the event to cross-promote his electric car company. Asked whether the Neuralink chip would allow people to summon their Tesla telepathically, buy kamagra oral jelly nz Musk responded. €œDefinitely — of course.”Matthew MacDougall, the company’s head neurosurgeon, appearing in scrubs, said the company had so far only implanted its technology into the brain’s cortical surface, the coaster-width layer enveloping the brain, but added that it hoped to go deeper in the future. Still, Musk buy kamagra oral jelly nz said. €œYou could solve blindness, you could solve paralysis, you could solve hearing — you can solve a lot just by interfacing with the cortex.”Musk and MacDougall said they hoped to eventually implant Neuralink’s devices — which they referred to on stage simply as “links” — in the deeper structures of the brain, such as in the hypothalamus, which is believed to play a critical role in mental illnesses including depression, anxiety, and PTSD.There were no updates at the event of Neuralink’s research in monkeys, which the company has been conducting in partnership with the University of California, Davis since 2017.

At last July’s event, Musk said — without providing evidence — that a monkey had controlled buy kamagra oral jelly nz a computer with its brain.At that same July 2019 event, Neuralink released a preprint paper — published a few months later — that claimed to show that a series of Neuralink electrodes implanted in the brains of rats could record neural signals. Critically, the work did not show where in the brain the implanted electrodes were recording from, for how long they were recording, or whether the recordings could be linked to any of the rats’ bodily movements.In touting Friday’s event — and Neuralink’s technological capabilities — on Twitter in recent weeks, Musk spoke of “AI symbiosis while u wait” and referenced the “matrix in the matrix” — a science-fiction reference about revealing the true nature of reality. The progress the buy kamagra oral jelly nz company reported on Friday fell far short of that. Neuralink’s prototype is ambitious, but it has yet to show evidence that it can match up to the brain-machine interfaces developed by academic labs and other companies. Other groups have shown that they can listen in on neural activity and buy kamagra oral jelly nz allow primates and people to control a computer cursor with their brain — so-called “read-out” technology — and have also shown that they can use electrical stimulation to input information, such as a command or the heat of a hot cup of coffee, using “write-in” technology.

Neuralink said on Friday that its technology would have both read-out and write-in capabilities.Musk acknowledged that Neuralink still has a long way to go. In closing the event after buy kamagra oral jelly nz more than 70 minutes, Musk said. €œThere’s a tremendous amount of work to be done to go from here to a device that is widely available and affordable and reliable.”Following the news this week of what appears to have been the first confirmed case of a Covid-19 reinfection, other researchers have been coming forward with their own reports. One in Belgium, another in the Netherlands buy kamagra oral jelly nz. And now, one in Nevada.What caught experts’ attention about the case of the 25-year-old Reno man was not that he appears to have contracted SARS-CoV-2 (the name of the virus that causes Covid-19) a second time.

Rather, it’s that his second bout was more serious than his first.Immunologists had expected that if the immune response generated after an initial infection could not prevent a second case, then it should at least stave off more severe buy kamagra oral jelly nz illness. That’s what occurred with the first known reinfection case, in a 33-year-old Hong Kong man.advertisement Still, despite what happened to the man in Nevada, researchers are stressing this is not a sky-is-falling situation or one that should result in firm conclusions. They always presumed people would become vulnerable to Covid-19 again some time after recovering from an initial case, based on how our immune systems respond to other respiratory viruses, including other coronaviruses buy kamagra oral jelly nz. It’s possible that these early cases of reinfection are outliers and have features that won’t apply to the tens of millions of other people who have already shaken off Covid-19.“There are millions and millions of cases,” said Michael Mina, an epidemiologist at Harvard’s T.H. Chan School of Public Health buy kamagra oral jelly nz.

The real question that should get the most focus, Mina said, is, “What happens to most people?. €advertisement But with more reinfection reports likely to make it into the scientific literature soon, and from there into buy kamagra oral jelly nz the mainstream press, here are some things to look for in assessing them.What’s the deal with the Nevada case?. The Reno resident in question first tested positive for SARS-CoV-2 in April after coming down with a sore throat, cough, and headache, as well as nausea and diarrhea. He got better buy kamagra oral jelly nz over time and later tested negative twice. But then, some 48 days later, the man started experiencing headaches, cough, and other symptoms again.

Eventually, he became so sick that he had to be hospitalized and was found to have pneumonia.Researchers sequenced virus samples from both of his infections and found they were different, providing evidence that this was a new infection distinct from the first. What happens when we buy kamagra oral jelly nz get Covid-19 in the first case?. Researchers are finding that, generally, people who get Covid-19 develop a healthy immune response replete with both antibodies (molecules that can block pathogens from infecting cells) and T cells (which help wipe out the virus). This is buy kamagra oral jelly nz what happens after other viral infections.In addition to fending off the virus the first time, that immune response also creates memories of the virus, should it try to invade a second time. It’s thought, then, that people who recover from Covid-19 will typically be protected from another case for some amount of time.

With other coronaviruses, protection is thought to last for perhaps a little less than a year to about three years.But researchers can’t tell how long immunity will last with a new pathogen (like SARS-CoV-2) until people buy kamagra oral jelly nz start getting reinfected. They also don’t know exactly what mechanisms provide protection against Covid-19, nor do they know what levels of antibodies or T cells are required to signal that someone is protected through a blood test. (These are called the “correlates of protection.”) Why do experts expect buy kamagra oral jelly nz second cases to be milder?. With other viruses, protective immunity doesn’t just vanish one day. Instead, it wanes over buy kamagra oral jelly nz time.

Researchers have then hypothesized that with SARS-CoV-2, perhaps our immune systems might not always be able to prevent it from getting a toehold in our cells — to halt infection entirely — but that it could still put up enough of a fight to guard us from getting really sick. Again, this is what buy kamagra oral jelly nz happens with other respiratory pathogens.And it’s why some researchers actually looked at the Hong Kong case with relief. The man had mild to moderate Covid-19 symptoms during the first case, but was asymptomatic the second time. It was a demonstration, experts said, of what buy kamagra oral jelly nz you would want your immune system to do. (The case was only detected because the man’s sample was taken at the airport when he arrived back in Hong Kong after traveling in Europe.)“The fact that somebody may get reinfected is not surprising,” Malik Peiris, a virologist at the University of Hong Kong, told STAT earlier this week about the first reinfection.

€œBut the reinfection didn’t cause disease, so that’s the first buy kamagra oral jelly nz point.”The Nevada case, then, provides a counterexample to that. What kind of immune response did the person who was reinfected generate initially?. Earlier, we described the robust buy kamagra oral jelly nz immune response that most people who have Covid-19 seem to mount. But that was a generalization. Infections and the immune responses they induce in different buy kamagra oral jelly nz people are “heterogeneous,” said Sarah Cobey, an epidemiologist and evolutionary biologist at the University of Chicago.Older people often generate weaker immune responses than younger people.

Some studies have also indicated that milder cases of Covid-19 induce tamer immune responses that might not provide as lasting or as thorough of a defense as stronger immune responses. The man in Hong buy kamagra oral jelly nz Kong, for example, did not generate antibodies to the virus after his first infection, at least to the level that could be detected by blood tests. Perhaps that explains why he contracted the virus again just about 4 1/2 months after recovering from his initial infection.In the Nevada case, researchers did not test what kind of immune response the man generated after the first case.“Infection is not some binary event,” Cobey said. And with reinfection, “there’s going to be some viral replication, but buy kamagra oral jelly nz the question is how much is the immune system getting engaged?. €What might be broadly meaningful is when people who mounted robust immune responses start getting reinfected, and how severe their second cases are.

Are buy kamagra oral jelly nz people who have Covid-19 a second time infectious?. As discussed, immune memory can prevent reinfection. If it can’t, it might stave buy kamagra oral jelly nz off serious illness. But there’s a third aspect of this, too.“The most important question for reinfection, with the most serious implications for controlling the pandemic, is whether reinfected people can transmit the virus to others,” Columbia University virologist Angela Rasmussen wrote in Slate this week.Unfortunately, neither the Hong Kong nor the Reno studies looked at this question. But if most people buy kamagra oral jelly nz who get reinfected don’t spread the virus, that’s obviously good news.

What happens when people broadly become susceptible again?. Whether it’s six months after the buy kamagra oral jelly nz first infection or nine months or a year or longer, at some point, protection for most people who recover from Covid-19 is expected to wane. And without the arrival of a vaccine and broad uptake of it, that could change the dynamics of local outbreaks.In some communities, it’s thought that more than 20% of residents have experienced an initial Covid-19 case, and are thus theoretically protected from another case for some time. That is still below the point of herd immunity — when enough people are immune that transmission doesn’t occur — but still, the fewer vulnerable people there are, the less likely spread is to occur.On the flip side though, if more people become susceptible to the virus again, that could increase buy kamagra oral jelly nz the risk of transmission. Modelers are starting to factor that possibility into their forecasts.A crucial question for which there is not an answer yet is whether what happened to the man in Reno, where the second case was more severe than the first, remains a rare occurrence, as researchers expect and hope.

As the Nevada researchers wrote, “the generalizability of this finding is unknown.”An advocacy group has asked the Department of Defense to investigate what it called “an apparent failure” buy kamagra oral jelly nz by Moderna (MRNA) to disclose millions of dollars in awards received from the Defense Advanced Research Projects Agency in patent applications the company filed for vaccines.In a letter to the agency, Knowledge Ecology International explained that a review of dozens of patent applications found the company received approximately $20 million from the federal government in grants several years ago and the funds “likely” led to the creation of its vaccine technology. This was used to develop vaccines to combat different viruses, such as Zika and, later, the virus that causes Covid-19.In arguing for an investigation, the advocacy group maintained Moderna is obligated under federal law to disclose the grants that led to nearly a dozen specific patent applications and explained the financial support means the U.S. Government would buy kamagra oral jelly nz have certain rights over the patents. In other words, U.S. Taxpayers would have an ownership stake in vaccines developed by the company.advertisement “This clarifies buy kamagra oral jelly nz the public’s right in the inventions,” said Jamie Love, who heads Knowledge Ecology International, a nonprofit that tracks patents and access to medicines issues.

€œThe disclosure (also) changes the narrative about who has financed the inventive activity, often the most risky part of development.” advertisement One particular patent assigned to Moderna concerns methods and compositions that can be used specifically against coronaviruses, including COVID-19. The patent names a Moderna scientist and a former Moderna scientist as inventors, both of which acknowledged performing work under the DARPA awards in two academic papers, according to the report by the advocacy group.The group examined the 126 patents assigned to Moderna or ModernaTx as well as 154 patent applications. €œDespite the evidence that multiple inventions were conceived in buy kamagra oral jelly nz the course of research supported by the DARPA awards, not a single one of the patents or applications assigned to Moderna disclose U.S. Federal government funding,” the report stated.We asked Moderna and the Department of Defense for comment and will update you accordingly.The missive to the Department of Defense follows a recent analysis by Public Citizen, another advocacy group, indicating the National Institutes of Health may own mRNA-1273, the Moderna vaccine candidate for Covid-19. The advocacy group noted the federal government filed multiple patents covering the vaccine and two patent applications, buy kamagra oral jelly nz in particular, list federal scientists as co-inventors.The analyses are part of a larger campaign among advocacy groups and others in the U.S.

And elsewhere to ensure that Covid-19 medical products are available to poor populations around the world. The concern buy kamagra oral jelly nz reflects the unprecedented global demand for therapies and vaccines, and a race among wealthy nations to snap up supplies from vaccine makers. In the U.S., the effort has focused on the extent to which the federal government has provided taxpayer dollars to different companies to help fund their discoveries. In some cases, advocates buy kamagra oral jelly nz argue that federal funding matters because it clarifies the rights that the U.S. Government has to ensure a therapy or vaccine is available to Americans on reasonable terms.One example has been remdesivir, the Gilead Sciences (GILD) treatment being given to hospitalized Covid-19 patients.

The role buy kamagra oral jelly nz played by the U.S. Government in developing remdesivir to combat coronaviruses involved contributions from government personnel at such agencies as the U.S. Army Medical Research Institute of Infectious Diseases.As for the Moderna vaccine, earlier this month, the company was awarded a $1.525 billion contract by the Department of Defense and the Department of Health and Human Services to manufacture and deliver 100 million doses of buy kamagra oral jelly nz its Covid-19 vaccine. The agreement also includes an option to purchase another 400 million doses, although the terms were not disclosed. In announcing the agreement, the government said it would ensure Americans receive the Covid-19 vaccine at no cost, although they may be charged by health care providers for administering a shot.In this instance, however, buy kamagra oral jelly nz Love said the “letter is not about price or profits.

It’s about (Moderna) not owning up to DARPA funding inventions. If the U.S buy kamagra oral jelly nz. Wants to pay for all of the development of Moderna’s vaccine, as Moderna now acknowledges, and throw in a few more billion now, and an option to spend billions more, it’s not unreasonable to have some transparency over who paid for their inventions.”This is not the first time Moderna has been accused of insufficient disclosure. Earlier this buy kamagra oral jelly nz month, Knowledge Ecology International and Public Citizen maintained the company failed to disclose development costs in a $955 million contract awarded by BARDA for its Covid-19 vaccine. In all, the federal government has awarded the company approximately $2.5 billion to develop the vaccine.The coming few weeks represent a crucial moment for an ambitious plan to try to secure Covid-19 vaccines for roughly 170 countries around the world without the deep pockets to compete for what will be scarce initial supplies.Under the plan, countries that want to pool resources to buy vaccines must notify the World Health Organization and other organizers — Gavi, the Vaccine Alliance, as well as the Coalition for Epidemic Preparedness Innovations — of their intentions by Monday.

That means it’s fish-or-cut-bait time buy kamagra oral jelly nz for the so-called COVAX facility.Already, wealthy countries — the United States, the United Kingdom, Japan, Canada, and Australia, among others, as well as the European Union — have opted to buy their own vaccine, signing bilateral contracts with manufacturers that have secured billions of doses of vaccine already. That raises the possibility that less wealthy countries will be boxed out of supplies.advertisement And yet Richard Hatchett, the CEO of CEPI, insists there is a path to billions of doses of vaccine for the rest of the world in 2021. STAT spoke with Hatchett this week buy kamagra oral jelly nz. A transcript of the conversation, lightly edited for clarity and length, follows. You said this is a buy kamagra oral jelly nz critical time for CEPI.

Can you explain what needs to happen between now and mid-September for this joint purchasing approach to be a success?. Advertisement The critical moment is now for countries to commit to the COVAX facility, because that will enable buy kamagra oral jelly nz us to secure ample quantities of vaccine and then to be able to convey when that vaccine is likely to become available based on current information.What we’re now here asking countries to do is to indicate their intent to participate by Aug. 31, and to make a binding commitment by Sept. 18. And to provide funds in support of that binding commitment by early October.

Our negotiations with companies are already taking place and it will be important for us from a planning purpose that countries indicate their intent to participate.Those binding commitments we think will be sufficient to allow us to then secure the advance purchase agreements, particularly with those companies that don’t have a prior contractual obligation to COVAX. And then obviously, we need the funds to live up to those advance purchase agreements.Is it possible this thing could still fall apart?. There appears to be some concern COVAX has been boxed out by rich countries. There was always a possibility that there wouldn’t be sufficient uptake. But I think we’re very encouraged at this point by the level of commitment, both from countries that would be beneficiaries of the advance market commitment — that’s the lower-income, lower-middle-income countries — as well as the self-financing countries.

To have over 170 countries expressing interest in participating — they see the value.We’re much more encouraged now that it’s not going to fall apart. We still need to bring it off to maximize its value. And we’re right at the crunch moment where countries are going to have to make these commitments. So, the next month is really absolutely critical to the facility. I am confident at this point that the world recognizes the value and wants it to work.I’ve been keeping tabs on advance purchase agreements that have been announced.

And at this point, a small number of rich countries have nailed down a lot of vaccine — more than 3 billion doses. How hard does that make your job?. The fact that they’re doing it creates anxiety among other countries. And that in itself can accelerate the pace. So, I’m not going to say that we’re not watching that with concern.I will say that for COVAX and the facility, this is absolutely critical moment.

I think we still have a window of opportunity between now and mid-September — when we’re asking that the self-financing countries to make their commitments — to make the facility real and to make it work. Between doses that are committed to COVAX through the access agreements and other agreements — these are discussions with partners that CEPI has funded as well as partners that CEPI has not funded — we still see a pathway for COVAX to well over 3 billion doses in 2021.I think it’s really important to bear in mind is that there are at least a few countries — and I think the U.S. And the U.K. Most publicly — that may be in a situation of significant oversupply. I believe the U.S.

And U.K. Numbers, if you add them together, would result in enough vaccine for 600 million people to receive two doses of vaccine each. And, you know, there is no possible way that the U.S. Or the U.K. Can use that much vaccine.So, there may be a lot of extra supply that looks like it’s been tied up sloshing around later.

I don’t think that the bilateral deals that have been struck are going to prevent COVAX from achieving its goals.But if so much vaccine has been pre-ordered by rich countries, can countries in the COVAX pool get enough for their needs?. One of the things that we’ve argued through COVAX is that to control the pandemic or to end the acute phase of the pandemic to allow normalcy to start to reassert itself, you don’t have to vaccinate 100% of your population.You need to vaccinate those at greatest risk for bad outcomes and you need to vaccinate certain critical workers, particularly your health care workforce. And if you can achieve that goal, which for most countries means vaccinating between 20% and maybe 30% of the population, then you can transform the pandemic into something that is much more manageable. Then you can buy yourself time to vaccinate everybody who wants to be vaccinated.We’ve argued the COVAX facility really offers the world the best shot at doing that globally in the fastest possible way, as well as providing for equitable access. This is a case where doing the equitable thing is also doing the efficient thing.CEPI has provided funding to nine vaccines.

Is it true that all those manufacturers aren’t required to provide the COVAX facility with vaccine?. That is correct. One of the things that we did, and I think it was an important role that CEPI played early on, was that we moved money very, very quickly, in small increments. You know, some of the early contracts were only $5 million or $10 million, to get programs up and running while we potentially put in place much larger-scale, longer-term contracts.If you were doing it over again, would you have given money without strings attached?. Yes, I think I would have.

I think that was critically important to initiating programs.Our contract with Moderna was established in about 48 hours. And that provided critical funding to them to manufacture doses that got them into clinical trials within nine weeks of the genetic sequences [of the SARS-CoV-2 virus] being released.And if you look at the nine programs that we’ve invested in, seven are in clinical trials. Two — the AstraZeneca program now and the Moderna program — are among the handful in Phase 3 clinical trials. And, I think the number of projects that that we funded initially, which started in kind of a biotech or academic phase that have now been picked up by large multinational corporations, there’s at least four. The Themis program being picked up by Merck, Oxford University by AstraZeneca, the University of Queensland by CSL, and Clover being in partnership with GSK, I think that speaks to the quality of the programs that we selected.So, I think that combination of rapid review, speed of funding, getting those programs started, getting them oriented in the right direction, I think all of that is critical to where we are now.Companies that got money from CEPI to build out production capacity — that money came with strings attached, right?.

Yes, exactly. So, where CEPI has made investments that create manufacturing, or secure manufacturing capacity, the commitment has been that the capacity that is attributable to the CEPI investment is committed — at least right of first refusal — to the global procurement facility.WASHINGTON — The Trump administration removed a top Food and Drug Administration communications official from her post on Friday in the wake of several controversial agency misstatements, a senior administration official confirmed to STAT.The spokeswoman, Emily Miller, had played a lead role in defending the FDA commissioner, Stephen Hahn, after he misrepresented data regarding the use of blood plasma from recovered Covid-19 patients. The New York Times first reported Miller’s ouster. Miller’s tenure at as the top FDA spokeswoman lasted only 11 days. Her appointment was viewed with alarm by agency officials who felt her presence at the agency was emblematic of broader political pressure from the Trump administration, STAT first reported earlier this week.advertisement Before joining the FDA, Miller had no experience in health or medicine.

Her former role as assistant commissioner for media affairs is typically not an appointment filled by political appointees. The FDA’s communications arm typically maintains a neutral, nonpolitical tone.Miller’s appointment particularly alarmed FDA staff and outside scientists given her history in right-wing political advocacy and conservatism journalism. Her résumé included a stint as a Washington Times columnist, where she penned columns with titles that include “New Obamacare ads make young women look like sluts,” and a 2013 book on gun rights titled “Emily Gets Her Gun. But Obama Wants to Take Yours.”advertisement She also worked as a reporter for One America News Network, a right-wing cable channel that frequently espouses conspiracy theories and has declared an open alliance with President Trump.Miller quickly made her presence known at the FDA. In the wake of Hahn’s misstatements on blood plasma, she aggressively defended the commissioner, falsely claiming in a tweet that the therapy “has shown to be beneficial for 35% of patients.” An FDA press release on blood plasma, issued less than a week after her appointment, similarly alarmed agency insiders by trumpeting the emergency authorization as “Another Achievement in Administration’s Fight Against [the] Pandemic.”.

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By Serena Gordon HealthDay Reporter how to get kamagra prescription can i buy kamagra over the counter TUESDAY, Sept. 8, 2020 (HealthDay News) -- Continuous positive airway pressure (CPAP) may be the go-to treatment for sleep apnea, but many people struggle to use it every night. For those who cannot tolerate CPAP, new research finds that a combination of surgical techniques may bring relief how to get kamagra prescription. The "multilevel" treatment includes removing the tonsils, repositioning the palate (roof of the mouth) and using radiofrequency to slightly reduce the size of the tongue. In combination, these procedures open up the airway and reduce breathing obstruction, the researchers said.

The study found that the multilevel surgery how to get kamagra prescription technique reduced the number of times people stopped breathing (apnea events) during sleep and improved daytime sleepiness. People also reported better quality of life after the treatment. "Obstructive sleep apnea is common and many people cannot use the main treatments, like CPAP masks. Surgery is a valid option when an expert surgeon is involved, how to get kamagra prescription and it can improve outcomes," said the study's lead author, Dr. Stuart MacKay.

He's an honorary clinical professor of otolaryngology, head and neck surgery at University of Wollongong, in Australia. The researchers said that nearly one billion how to get kamagra prescription people worldwide suffer from sleep apnea. The airway becomes blocked during sleep, and as a result people stop breathing for short periods of time, multiple times throughout the night. People with sleep apnea have a higher risk of daytime sleepiness, motor vehicle crashes, and heart disease and stroke. CPAP does a good job at keeping your airway open as you sleep, but the how to get kamagra prescription treatment -- including a mask and a long tube -- can be hard to get used to.

The study authors said only about half of people with sleep apnea try CPAP. For the new study, the researchers recruited 102 overweight or obese people with sleep apnea from six clinical centers in Australia, who were in their 40s, on average. The goal was to see if surgery could help adults with moderate or severe obstructive sleep how to get kamagra prescription apnea who weren't able to tolerate or adhere to CPAP devices. Half of the volunteers were randomly assigned to receive the sleep apnea surgery, while the other 51 continued with medical treatment. Medical management how to get kamagra prescription consisted of encouraging weight loss, drinking less alcohol, changing sleep posture and medical treatment for nasal obstruction.

Continued MacKay said the multilevel surgical technique is widely available in many parts of the world. For the patients in this study, surgeries were performed by seven experienced surgeons. Six months after the surgical procedures, volunteers in the surgery group how to get kamagra prescription had about a 27% decrease in the number of apnea events at night. Those on medical treatment had just a 10% decrease. People in the surgical group also had major improvements in levels of snoring and daytime sleepiness, as well as a boost to quality of life.

As with any how to get kamagra prescription surgical procedure, there are risks. "The main risks of pain and bleeding are confined to the two weeks after surgery. Bleeding occurs in about one in every 25 patients. Long-term risks related to taste disturbance, feeling of sticking in the throat, swallow dysfunction are very rare, although they do occur transiently in how to get kamagra prescription some," MacKay said. Dr.

Steven Feinsilver is director of the Center for Sleep Medicine at Lenox Hill Hospital in New York City. He said, "Sleep apnea is a very common disease, how to get kamagra prescription about as common as diabetes, and similar to diabetes is associated with increased risk for cardiovascular events, such as stroke and heart disease." He added that "CPAP works, but is a difficult treatment." Feinsilver said that surgery that could provide a permanent cure has long been the goal for treatment. "This study shows that relatively minor surgery, performed in a standardized fashion by skilled surgeons, can significantly improve sleep apnea compared to 'medical treatment' (essentially no treatment)," he said. But he noted that even though people reported improvement, their nighttime breathing wasn't back in the normal range. "This is certainly a major improvement, but it remains unclear whether how to get kamagra prescription outcomes (such as cardiovascular risk) will be significantly impacted," Feinsilver said.

Also, he suggested that this multilevel surgery may only be an option for a select group of patients. The report was published online Sept. 4 in click this the Journal of the American Medical Association how to get kamagra prescription. WebMD News from HealthDay Sources SOURCES. Stuart MacKay, MD, honorary clinical professor, otolaryngology, head and neck how to get kamagra prescription surgery, University of Wollongong, Australia.

Steven Feinsilver, MD, director, Center for Sleep Medicine, Lenox Hill Hospital, New York City;Journal of the American Medical Association, Sept. 4, 2020, online Copyright © 2013-2020 HealthDay. All rights how to get kamagra prescription reserved.TUESDAY, Sept. 8, 2020 (HealthDay News) -- New research reveals what may be fueling racial disparities in U.S. Prostate cancer deaths -- disparities that have black patients dying at higher rates than whites.

What are how to get kamagra prescription they?. Education, income and insurance. "Socioeconomic status and insurance status are all changeable factors. Unfortunately, the socioeconomic status inequality in the United States has continued to increase over the past how to get kamagra prescription decades," said study author Dr. Wanqing Wen, from Vanderbilt University's School of Medicine in Nashville, Tenn.

Wen and his team analyzed U.S. National Cancer Database data on men with prostate cancer how to get kamagra prescription who had their prostate removed between 2001 and 2014. The analysis included more than 432,000 whites, more than 63,000 Blacks, nearly 9,000 Asian-American and Pacific Islanders (AAPI), and more than 21,000 Hispanics. Five-year survival rates were 96.2% among whites, 94.9% among Blacks, 96.8% among AAPIs, and 96.5% among Hispanics. After adjusting for age and year of prostate cancer diagnosis, the researchers found that Blacks had a 51% higher death rate than whites, while AAPIs and how to get kamagra prescription Hispanics had 22% and 6% lower rates than whites, respectively.

After researchers adjusted for all clinical factors and non-clinical factors, Blacks had a 20% higher risk of death than whites, while AAPIs had a 35% lower risk than whites. The disparity between Hispanics and how to get kamagra prescription whites remained similar. Of the factors included in the team's adjustments, education, median household income and insurance status had the greatest impact on racial disparities. For example, if Blacks and whites had similar education levels, median household income and insurance status, the survival disparity would decrease from 51% to 30%, according to the study published Sept. 8 in the journal how to get kamagra prescription Cancer.

"We hope our study findings can enhance public awareness that the racial survival difference, particularly between Black and white prostate patients, can be narrowed by erasing the racial inequities in socioeconomic status and health care," Wen said in a journal news release. "Effectively disseminating our findings to the public and policymakers is an important step towards this goal." September is Prostate Cancer Awareness Month.Michael Fischman, MD, consulting doctor in occupational and environmental medicine and toxicology, Walnut Creek, CA. Clinical professor of medicine, University of California, how to get kamagra prescription San Francisco. Denise Bender, assistant director, occupational safety and health, environmental health and safety department, University of Washington, Seattle. University of Washington.

"University of Washington Guidance how to get kamagra prescription for Plexiglass Barriers in Support of Covid-19 Prevention Efforts." American College of Occupational and Environmental Medicine. "COVID-19 Resource Center." The New England Journal of Medicine. "Barrier Enclosure during Endotracheal Intubation." Gastrointestinal Endoscopy. "Plexiglas barrier box to prove ERCP safety during the COVID-19 pandemic." News release, Plex'Eat. "The Innovative Design Solution Launches Its Large-Scale Production." Al Luevanos, manager, Milt &.

Edie's Drycleaners, Burbank, CA. Kayla Stark, employee, Milt &. Edie's Drycleaners, Burbank, CA. Dave Heylen, spokesperson, California Grocers Association, Sacramento..

By Serena buy kamagra oral jelly nz http://sw.keimfarben.de/kamagra-online-review/ Gordon HealthDay Reporter TUESDAY, Sept. 8, 2020 (HealthDay News) -- Continuous positive airway pressure (CPAP) may be the go-to treatment for sleep apnea, but many people struggle to use it every night. For those who cannot buy kamagra oral jelly nz tolerate CPAP, new research finds that a combination of surgical techniques may bring relief. The "multilevel" treatment includes removing the tonsils, repositioning the palate (roof of the mouth) and using radiofrequency to slightly reduce the size of the tongue. In combination, these procedures open up the airway and reduce breathing obstruction, the researchers said.

The study found that the multilevel buy kamagra oral jelly nz surgery technique reduced the number of times people stopped breathing (apnea events) during sleep and improved daytime sleepiness. People also reported better quality of life after the treatment. "Obstructive sleep apnea is common and many people cannot use the main treatments, like CPAP masks. Surgery is buy kamagra oral jelly nz a valid option when an expert surgeon is involved, and it can improve outcomes," said the study's lead author, Dr. Stuart MacKay.

He's an honorary clinical professor of otolaryngology, head and neck surgery at University of Wollongong, in Australia. The researchers said that buy kamagra oral jelly nz nearly one billion people worldwide suffer from sleep apnea. The airway becomes blocked during sleep, and as a result people stop breathing for short periods of time, multiple times throughout the night. People with sleep apnea have a higher risk of daytime sleepiness, motor vehicle crashes, and heart disease and stroke. CPAP does a good job at keeping your airway open as you sleep, but the treatment -- including a mask and a long tube -- can be hard to get buy kamagra oral jelly nz used to.

The study authors said only about half of people with sleep apnea try CPAP. For the new study, the researchers recruited 102 overweight or obese people with sleep apnea from six clinical centers in Australia, who were in their 40s, on average. The goal was to see if surgery could help adults with moderate or severe obstructive sleep apnea who weren't able to tolerate or adhere to CPAP buy kamagra oral jelly nz devices. Half of the volunteers were randomly assigned to receive the sleep apnea surgery, while the other 51 continued with medical treatment. Medical management consisted of encouraging weight loss, drinking less alcohol, changing sleep posture buy kamagra oral jelly nz and medical treatment for nasal obstruction.

Continued MacKay said the multilevel surgical technique is widely available in many parts of the world. For the patients in this study, surgeries were performed by seven experienced surgeons. Six months buy kamagra oral jelly nz after the surgical procedures, volunteers in the surgery group had about a 27% decrease in the number of apnea events at night. Those on medical treatment had just a 10% decrease. People in the surgical group also had major improvements in levels of snoring and daytime sleepiness, as well as a boost to quality of life.

As with any surgical buy kamagra oral jelly nz procedure, there are risks. "The main risks of pain and bleeding are confined to the two weeks after surgery. Bleeding occurs in about one in every 25 patients. Long-term risks related to taste disturbance, feeling of sticking in the throat, buy kamagra oral jelly nz swallow dysfunction are very rare, although they do occur transiently in some," MacKay said. Dr.

Steven Feinsilver is director of the Center for Sleep Medicine at Lenox Hill Hospital in New York City. He said, "Sleep apnea is a very common disease, about as common as diabetes, and similar to diabetes is associated with increased risk for cardiovascular events, such as stroke and heart disease." He added that "CPAP works, but is a difficult treatment." Feinsilver said that surgery buy kamagra oral jelly nz that could provide a permanent cure has long been the goal for treatment. "This study shows that relatively minor surgery, performed in a standardized fashion by skilled surgeons, can significantly improve sleep apnea compared to 'medical treatment' (essentially no treatment)," he said. But he noted that even though people reported improvement, their nighttime breathing wasn't back in the normal range. "This is certainly a major buy kamagra oral jelly nz improvement, but it remains unclear whether outcomes (such as cardiovascular risk) will be significantly impacted," Feinsilver said.

Also, he suggested that this multilevel surgery may only be an option for a select group of patients. The report was published online Sept. 4 in the Journal of buy kamagra oral jelly nz the http://sw.keimfarben.de/kamagra-for-sale/ American Medical Association. WebMD News from HealthDay Sources SOURCES. Stuart MacKay, MD, honorary clinical professor, buy kamagra oral jelly nz otolaryngology, head and neck surgery, University of Wollongong, Australia.

Steven Feinsilver, MD, director, Center for Sleep Medicine, Lenox Hill Hospital, New York City;Journal of the American Medical Association, Sept. 4, 2020, online Copyright © 2013-2020 HealthDay. All rights buy kamagra oral jelly nz reserved.TUESDAY, Sept. 8, 2020 (HealthDay News) -- New research reveals what may be fueling racial disparities in U.S. Prostate cancer deaths -- disparities that have black patients dying at higher rates than whites.

What are they? buy kamagra oral jelly nz. Education, income and insurance. "Socioeconomic status and insurance status are all changeable factors. Unfortunately, the socioeconomic status buy kamagra oral jelly nz inequality in the United States has continued to increase over the past decades," said study author Dr. Wanqing Wen, from Vanderbilt University's School of Medicine in Nashville, Tenn.

Wen and his team analyzed U.S. National Cancer Database data on buy kamagra oral jelly nz men with prostate cancer who had their prostate removed between 2001 and 2014. The analysis included more than 432,000 whites, more than 63,000 Blacks, nearly 9,000 Asian-American and Pacific Islanders (AAPI), and more than 21,000 Hispanics. Five-year survival rates were 96.2% among whites, 94.9% among Blacks, 96.8% among AAPIs, and 96.5% among Hispanics. After adjusting for age and year of prostate cancer diagnosis, the researchers found that Blacks had a 51% higher death rate than whites, while AAPIs and Hispanics had 22% buy kamagra oral jelly nz and 6% lower rates than whites, respectively.

After researchers adjusted for all clinical factors and non-clinical factors, Blacks had a 20% higher risk of death than whites, while AAPIs had a 35% lower risk than whites. The disparity buy kamagra oral jelly nz between Hispanics and whites remained similar. Of the factors included in the team's adjustments, education, median household income and insurance status had the greatest impact on racial disparities. For example, if Blacks and whites had similar education levels, median household income and insurance status, the survival disparity would decrease from 51% to 30%, according to the study published Sept. 8 in buy kamagra oral jelly nz the journal Cancer.

"We hope our study findings can enhance public awareness that the racial survival difference, particularly between Black and white prostate patients, can be narrowed by erasing the racial inequities in socioeconomic status and health care," Wen said in a journal news release. "Effectively disseminating our findings to the public and policymakers is an important step towards this goal." September is Prostate Cancer Awareness Month.Michael Fischman, MD, consulting doctor in occupational and environmental medicine and toxicology, Walnut Creek, CA. Clinical professor of medicine, University buy kamagra oral jelly nz of California, San Francisco. Denise Bender, assistant director, occupational safety and health, environmental health and safety department, University of Washington, Seattle. University of Washington.

"University of Washington Guidance for Plexiglass Barriers in Support of Covid-19 Prevention Efforts." American College of Occupational and Environmental buy kamagra oral jelly nz Medicine. "COVID-19 Resource Center." The New England Journal of Medicine. "Barrier Enclosure during Endotracheal Intubation." Gastrointestinal Endoscopy. "Plexiglas barrier box to prove ERCP safety during buy kamagra oral jelly nz the COVID-19 pandemic." News release, Plex'Eat. "The Innovative Design Solution Launches Its Large-Scale Production." Al Luevanos, manager, Milt &.

Edie's Drycleaners, Burbank, CA. Kayla Stark, employee, Milt & buy kamagra oral jelly nz. Edie's Drycleaners, Burbank, CA. Dave Heylen, spokesperson, California Grocers Association, Sacramento..

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Rather than treating the mechanical consequences of severe CAVS, identification of causal disease pathways http://sw.keimfarben.de/buy-kamagra-online-without-prescription/ at the tissue level might lead to medical therapies that how to get kamagra in the us could actually prevent or delay the pathological changes in the valve leaflets. Serum levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity are associated with the presence of CAVS. However, it has been unclear whether this association is due to a cause–effect relationship.

In this issue of Heart, Perrot and colleagues1 used genetic association studies from eight cohorts to show that CAVS was not associated with any of four single nucleotide polymorphisms how to get kamagra in the us that are associated with Lp-PLA2 activity or mass. These findings suggest that although Lp-PLA2 activity is a biomarker for CAVS unfortunately, it is unlikely to be a therapeutic target (figure 1).Higher Lp-PLA2 activity is significantly associated with the presence of CAVS in patients with heart disease, but variants influencing Lp-PLA2 mass or activity are not associated with CAVS in this large genetic association study. CAVS, calcific aortic valve stenosis.

Lp-PLA2, lipoprotein-associated phospholipase A2." data-icon-position data-hide-link-title="0">Figure 1 Higher Lp-PLA2 activity is significantly associated with the presence of CAVS in patients with heart disease, but variants influencing Lp-PLA2 how to get kamagra in the us mass or activity are not associated with CAVS in this large genetic association study. CAVS, calcific aortic valve stenosis. Lp-PLA2, lipoprotein-associated phospholipase A2.In an editorial, Zheng and Dweck2 discuss this article, summarise current ongoing trials of medical therapy for CAVS (table 1) and comment.

€˜Strong evidence points towards how to get kamagra in the us elevated Lp(a) levels and its associated oxidised phospholipids (OxPL) as causal risk factors for CAVS, suggesting that targeting this lipid-driven, inflammatory pathway has a real chance to translate into therapy capable of mitigating disease. The current study suggests that this association is not mediated by Lp-PLA2 and underlines the importance of scrutinising whether biological factors within pathophysiological pathways are merely biomarkers or actually represent a feasible and causal target.’View this table:Table 1 Ongoing randomised clinical trials of medical therapies in aortic stenosisRheumatic heart disease (RHD) remains the primary cause of valve disease worldwide and contributes significantly to maternal and fetal morbidity and mortality. In a study by Baghel and colleagues3 of 681 pregnant women with RHD, adverse cardiovascular evens occurred in about 15% of pregnancies.

Multivariable predictors of adverse outcomes during pregnancy were prior how to get kamagra in the us adverse cardiovascular events, lack of appropriate medical therapy, severity of mitral stenosis, valve replacement and pulmonary hypertension. Based on this analysis, the authors propose a risk score from pregnant women with RHD (table 2).View this table:Table 2 New prognostic score (DEVI’s score) to predict composite adverse cardiac outcome in pregnant women with rheumatic valvular heart diseaseCommenting on this paper, Elkayam and Shmueli4 point out that in about one-fourth of women, the diagnosis of RHD was not known prior to pregnancy and that a late diagnosis often was associated with adverse outcomes. Their editorial provides a concise summary of optimal management of pregnant women with RHD.

They conclude ‘With proper evaluation and risk stratification prior to pregnancy, a close multidisciplinary follow-up during pregnancy, and close monitoring during labour and delivery how to get kamagra in the us as well as the early postpartum period most complications can be prevented.’The importance of psychosocial factors in cardiovascular disease (CVD) prevalence and outcomes is increasingly recognised. Using data from the English Longitudinal Study of Ageing, Bu and colleagues5 found that loneliness was associated with CVD, independent of possible confounders and other risk factors, with a 30% higher risk of a new CVD diagnosis in the most lonely people compared with the least lonely people. As O’Keefe and colleagues6 point out, this data is especially important now in the context of social distancing and stay-at-home recommendations and they offer several approaches to mitigating loneliness during the COVID-19 pandemic.The Education in Heart article7 in this issue focuses on the clinical use and prognostic implications of echocardiographic speckle tracking measurements of global longitudinal strain to detect and quantify early systolic dysfunction of the left ventricle (figure 2).Left ventricular global longitudinal strain to differentiate between mutation-positive sarcomeric hypertrophic cardiomyopathy and cardiac amyloidosis.

(A) Apical four-chamber how to get kamagra in the us view of a 66-year-old patient known with mutation-positive hypertrophic cardiomyopathy. The thickness of the septum was 28 mm and the left ventricular ejection fraction was 55%. (B) The polar map shows markedly impaired longitudinal strain in the septal mid and basal areas and the global longitudinal strain is impaired (−13.6%).

(C) Apical four-chamber view of a 75-year-old patient diagnosed with light chain amyloidosis how to get kamagra in the us. There is concentric hypertrophy of the left ventricle and the ejection fraction is 56%. Based on speckle tracking echocardiography analysis, the left ventricular global longitudinal strain is impaired (−12.2%), with typical sparing of the longitudinal strain values in the apical segments (D).

ANT, anterior how to get kamagra in the us. ANT SEPT, anteroseptal. GS, global strain.

INF, inferior. LAT, lateral how to get kamagra in the us http://sw.keimfarben.de/how-to-get-kamagra-in-the-us/. POST, posterior.

SEPT, septal." data-icon-position data-hide-link-title="0">Figure 2 Left ventricular global longitudinal strain to differentiate between mutation-positive sarcomeric hypertrophic cardiomyopathy and cardiac amyloidosis. (A) Apical how to get kamagra in the us four-chamber view of a 66-year-old patient known with mutation-positive hypertrophic cardiomyopathy. The thickness of the septum was 28 mm and the left ventricular ejection fraction was 55%.

(B) The polar map shows markedly impaired longitudinal strain in the septal mid and basal areas and the global longitudinal strain is impaired (−13.6%). (C) Apical four-chamber view of a 75-year-old how to get kamagra in the us patient diagnosed with light chain amyloidosis. There is concentric hypertrophy of the left ventricle and the ejection fraction is 56%.

Based on speckle tracking echocardiography analysis, the left ventricular global longitudinal strain is impaired (−12.2%), with typical sparing of the longitudinal strain values in the apical segments (D). ANT, anterior how to get kamagra in the us. ANT SEPT, anteroseptal.

GS, global strain. INF, inferior how to get kamagra in the us. LAT, lateral.

POST, posterior. SEPT, septal.Our Cardiology-in-Focus article by Hudson and Pettit8 provides a clear-eyed but brief discussion and outstanding graphic of the challenges in how to get kamagra in the us reconciling the varying definitions of the ‘normal’ values for left ventricular ejection fraction, as stated in different guidelines (figure 3).Categories of left ventricular ejection fraction. EF, ejection fraction.

HF, heart failure. LVEF, left ventricular ejection fraction." data-icon-position data-hide-link-title="0">Figure 3 Categories of left ventricular ejection how to get kamagra in the us fraction. EF, ejection fraction.

HF, heart failure. LVEF, left ventricular ejection fraction.Loneliness how to get kamagra in the us is an unpleasant emotional state induced by perceived isolation. Until about 200 years ago, the English word for being on one’s own was ‘oneliness’, a term that connoted solitude, and was generally considered an essential and positive experience in life.

However, solitude and loneliness are not synonymous. Loneliness is also described as ‘social pain’ from an unwanted how to get kamagra in the us lack of connection and intimacy. Artists have likened loneliness to hunger, not only because we can feel it physically, sometimes described as an ache, a hollowness or a sense of coldness, but also because these physical sensations might be the body’s way of telling us that we are missing something that is important to our survival and flourishing.In this issue of Heart, Bu and colleagues,1 in a prospective observational study that comprised approximately 5000 adults followed for about 10 years, found that individuals reporting high levels of loneliness had 30%–48% increased risks of developing cardiovascular disease (CVD) and CVD-related hospital admission, respectively, even after adjusting for the usual cardiovascular risk factors.1 This major study has three implications.

(1) loneliness should be considered among the most dangerous CVD risk factors. (2) feeling lonely is a highly modifiable state that would seemingly respond to lifestyle adjustments as compared with the other foremost psychosocial CVD risk factors—depression and stress/anxiety—which typically require prescription medication or exercise2.

Serum levels buy kamagra oral jelly nz of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity are associated with the presence of CAVS discover this info here. However, it has been unclear whether this association is due to a cause–effect relationship. In this issue of Heart, Perrot and colleagues1 used genetic association studies from eight cohorts to show that CAVS was not associated with any of four single nucleotide polymorphisms that are associated with Lp-PLA2 activity or mass. These findings suggest that although Lp-PLA2 activity is a biomarker buy kamagra oral jelly nz for CAVS unfortunately, it is unlikely to be a therapeutic target (figure 1).Higher Lp-PLA2 activity is significantly associated with the presence of CAVS in patients with heart disease, but variants influencing Lp-PLA2 mass or activity are not associated with CAVS in this large genetic association study. CAVS, calcific aortic valve stenosis.

Lp-PLA2, lipoprotein-associated phospholipase A2." data-icon-position data-hide-link-title="0">Figure 1 Higher Lp-PLA2 activity is significantly associated with the presence of CAVS in patients with heart disease, but variants influencing Lp-PLA2 mass or activity are not associated with CAVS in this large genetic association study. CAVS, calcific aortic valve stenosis buy kamagra oral jelly nz. Lp-PLA2, lipoprotein-associated phospholipase A2.In an editorial, Zheng and Dweck2 discuss this article, summarise current ongoing trials of medical therapy for CAVS (table 1) and comment. €˜Strong evidence points towards elevated Lp(a) levels and its associated oxidised phospholipids (OxPL) as causal risk factors for CAVS, suggesting that targeting this lipid-driven, inflammatory pathway has a real chance to translate into therapy capable of mitigating disease. The current study suggests that this association is not mediated by Lp-PLA2 and underlines the importance of scrutinising whether biological factors within pathophysiological pathways are merely biomarkers or actually represent a feasible and causal target.’View this table:Table 1 Ongoing randomised clinical trials of medical therapies in buy kamagra oral jelly nz aortic stenosisRheumatic heart disease (RHD) remains the primary cause of valve disease worldwide and contributes significantly to maternal and fetal morbidity and mortality.

In a study by Baghel and colleagues3 of 681 pregnant women with RHD, adverse cardiovascular evens occurred in about 15% of pregnancies. Multivariable predictors of adverse outcomes during pregnancy were prior adverse cardiovascular events, lack of appropriate medical therapy, severity of mitral stenosis, valve replacement and pulmonary hypertension. Based on this analysis, the authors propose buy kamagra oral jelly nz a risk score from pregnant women with RHD (table 2).View this table:Table 2 New prognostic score (DEVI’s score) to predict composite adverse cardiac outcome in pregnant women with rheumatic valvular heart diseaseCommenting on this paper, Elkayam and Shmueli4 point out that in about one-fourth of women, the diagnosis of RHD was not known prior to pregnancy and that a late diagnosis often was associated with adverse outcomes. Their editorial provides a concise summary of optimal management of pregnant women with RHD. They conclude ‘With proper evaluation and risk stratification prior to pregnancy, a close multidisciplinary follow-up during pregnancy, and close monitoring during labour and delivery as well as the early postpartum period most complications can be prevented.’The importance of psychosocial factors in cardiovascular disease (CVD) prevalence and outcomes is increasingly recognised.

Using data from the English Longitudinal Study of Ageing, Bu and colleagues5 found that loneliness was associated with CVD, independent of possible confounders and other risk factors, with a 30% higher risk of a new CVD diagnosis in the most lonely people compared buy kamagra oral jelly nz with the least lonely people. As O’Keefe and colleagues6 point out, this data is especially important now in the context of social distancing and stay-at-home recommendations and they offer several approaches to mitigating loneliness during the COVID-19 pandemic.The Education in Heart article7 in this issue focuses on the clinical use and prognostic implications of echocardiographic speckle tracking measurements of global longitudinal strain to detect and quantify early systolic dysfunction of the left ventricle (figure 2).Left ventricular global longitudinal strain to differentiate between mutation-positive sarcomeric hypertrophic cardiomyopathy and cardiac amyloidosis. (A) Apical four-chamber view of a 66-year-old patient known with mutation-positive hypertrophic cardiomyopathy. The thickness buy kamagra oral jelly nz of the septum was 28 mm and the left ventricular ejection fraction was 55%. (B) The polar map shows markedly impaired longitudinal strain in the septal mid and basal areas and the global longitudinal strain is impaired (−13.6%).

(C) Apical four-chamber view of a 75-year-old patient diagnosed with light chain amyloidosis. There is concentric hypertrophy of the left ventricle and the ejection buy kamagra oral jelly nz fraction is 56%. Based on speckle tracking echocardiography analysis, the left ventricular global longitudinal strain is impaired (−12.2%), with typical sparing of the longitudinal strain values in the apical segments (D). ANT, anterior. ANT SEPT, buy kamagra oral jelly nz anteroseptal.

GS, global strain. INF, inferior. LAT, lateral. POST, posterior buy kamagra oral jelly nz http://sw.keimfarben.de/how-to-get-kamagra-in-the-us/. SEPT, septal." data-icon-position data-hide-link-title="0">Figure 2 Left ventricular global longitudinal strain to differentiate between mutation-positive sarcomeric hypertrophic cardiomyopathy and cardiac amyloidosis.

(A) Apical four-chamber view of a 66-year-old patient known with mutation-positive hypertrophic cardiomyopathy. The thickness of buy kamagra oral jelly nz the septum was 28 mm and the left ventricular ejection fraction was 55%. (B) The polar map shows markedly impaired longitudinal strain in the septal mid and basal areas and the global longitudinal strain is impaired (−13.6%). (C) Apical four-chamber view of a 75-year-old patient diagnosed with light chain amyloidosis. There is concentric buy kamagra oral jelly nz hypertrophy of the left ventricle and the ejection fraction is 56%.

Based on speckle tracking echocardiography analysis, the left ventricular global longitudinal strain is impaired (−12.2%), with typical sparing of the longitudinal strain values in the apical segments (D). ANT, anterior. ANT SEPT, buy kamagra oral jelly nz anteroseptal. GS, global strain. INF, inferior.

LAT, lateral buy kamagra oral jelly nz. POST, posterior. SEPT, septal.Our Cardiology-in-Focus article by Hudson and Pettit8 provides a clear-eyed but brief discussion and outstanding graphic of the challenges in reconciling the varying definitions of the ‘normal’ values for left ventricular ejection fraction, as stated in different guidelines (figure 3).Categories of left ventricular ejection fraction. EF, ejection buy kamagra oral jelly nz fraction. HF, heart failure.

LVEF, left ventricular ejection fraction." data-icon-position data-hide-link-title="0">Figure 3 Categories of left ventricular ejection fraction. EF, ejection fraction buy kamagra oral jelly nz. HF, heart failure. LVEF, left ventricular ejection fraction.Loneliness is an unpleasant emotional state induced by perceived isolation. Until about 200 years ago, buy kamagra oral jelly nz the English word for being on one’s own was ‘oneliness’, a term that connoted solitude, and was generally considered an essential and positive experience in life.

However, solitude and loneliness are not synonymous. Loneliness is also described as ‘social pain’ from an unwanted lack of connection and intimacy. Artists have likened loneliness to hunger, not only because we can feel it physically, sometimes described as an ache, a hollowness or a sense of coldness, but also because these physical sensations might be the body’s way of telling us that we are missing something that is important to our survival and flourishing.In this issue of Heart, Bu and colleagues,1 in a prospective observational study that comprised approximately 5000 adults followed for about 10 years, found that individuals reporting high levels of loneliness had 30%–48% increased risks of developing cardiovascular disease (CVD) and CVD-related hospital admission, respectively, even after adjusting for the usual cardiovascular risk buy kamagra oral jelly nz factors.1 This major study has three implications. (1) loneliness should be considered among the most dangerous CVD risk factors. (2) feeling lonely is a highly modifiable state that would seemingly respond to lifestyle adjustments as compared with the other foremost psychosocial CVD risk factors—depression and stress/anxiety—which typically require prescription medication or exercise2.

And (3) social isolation without the anguish of loneliness does not appear to increase CVD risk.The current study confirms prior data showing that self-reported loneliness is significantly correlated with increased healthcare utilisation and heightened morbidity and mortality risks.3 4 Advanced age, poor health, fewer ….